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Titolo:
CD8(+) cytotoxic lymphocyte responses against cytomegalovirus after liver transplantation: Correlation with time from transplant to receipt of tacrolimus
Autore:
Hassan-Walker, AF; Cuero, ALV; Mattes, FM; Klenerman, P; Lechner, F; Burroughs, AK; Griffiths, PD; Phillips, RE; Emery, VC;
Indirizzi:
Royal Free & Univ Coll Med Sch, Dept Virol, London NW3 2PF, England Royal Free & Univ Coll Med Sch London England NW3 2PF n NW3 2PF, England Royal Free Hampstead Natl Hlth Serv Trust, Div Hepatobiliary Med, London, England Royal Free Hampstead Natl Hlth Serv Trust London England ondon, England Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Med, Oxford OX3 9DU, England Univ Oxford Oxford England OX3 9DU ept Clin Med, Oxford OX3 9DU, England
Titolo Testata:
JOURNAL OF INFECTIOUS DISEASES
fascicolo: 6, volume: 183, anno: 2001,
pagine: 835 - 843
SICI:
0022-1899(20010315)183:6<835:CCLRAC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL-ALLOGRAFT RECIPIENTS; EPSTEIN-BARR-VIRUS; T-LYMPHOCYTES; CMV DISEASE; DIRECT VISUALIZATION; PROTEIN PP65; RISK-FACTORS; IN-VIVO; INFECTION; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Emery, VC Royal Free & Univ Coll Med Sch, Dept Virol, Royal Free Campus,Rowland Hillst, London NW3 2PF, England Royal Free & Univ Coll Med Sch Royal Free Campus,Rowland Hill st London England NW3 2PF
Citazione:
A.F. Hassan-Walker et al., "CD8(+) cytotoxic lymphocyte responses against cytomegalovirus after liver transplantation: Correlation with time from transplant to receipt of tacrolimus", J INFEC DIS, 183(6), 2001, pp. 835-843

Abstract

The effects of the immunocompromised state after liver transplantation on the frequency of cytomegalovirus-specific cytotoxic T lymphocytes (CTL) were investigated in 93 patients by using HLA class I tetrameric complexes corresponding to HLA-A*0201, HLA-B*0702, HLA-B*0801, and HLA-B*3501 refolded with peptides from the ppUL83 matrix protein. ppUL83 CTL frequencies were suppressed during the first 6 months after transplantation. Patients with >1 HLA-restricted response detected had high correlation among ppUL83 CD8(+) CTL frequencies restricted by different HLA haplotypes (Spearman's rho = .67; P < .0001). There was an inverse correlation among levels of the calcineurin inhibitor, tacrolimus, and ppUL83 CD8(+) CTL frequencies (r = -.31; P =.005), which is consistent with the presence of a large proportion (70%) of activated (CD38(+)) ppUL83 CD8+ CTL within the population of HLA class I tetramer-positive cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 22:27:14