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Titolo:
Contribution of Th1 and Th2 cells to protection and pathology in experimental models of granulomatous lung disease
Autore:
Wangoo, A; Sparer, T; Brown, IN; Snewin, VA; Janssen, R; Thole, J; Cook, HT; Shaw, RJ; Young, DB;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Infect Dis & Microbiol, London W2 1PG, England Univ London Imperial Coll Sci Technol & Med London England W2 1PG ngland Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Histopathol, London W2 1PG, England Univ London Imperial Coll Sci Technol & Med London England W2 1PG ngland Natl Heart & Lung Inst, Dept Resp Med, London, England Natl Heart & Lung Inst London England t, Dept Resp Med, London, England
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 5, volume: 166, anno: 2001,
pagine: 3432 - 3439
SICI:
0022-1767(20010301)166:5<3432:COTATC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYCOBACTERIUM-TUBERCULOSIS INFECTION; CYTOKINE GENE ACTIVATION; T-CELLS; INTERFERON-GAMMA; PHENOTYPE DEVELOPMENT; SCHISTOSOMA-MANSONI; ANTIGEN-RECEPTOR; MESSENGER-RNA; IFN-GAMMA; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Young, DB Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Infect Dis & Microbiol, St Marys Campus,Norfolk Pl, London W2 1PG, England Univ London Imperial Coll Sci Technol & Med St Marys Campus,Norfolk Pl London England W2 1PG
Citazione:
A. Wangoo et al., "Contribution of Th1 and Th2 cells to protection and pathology in experimental models of granulomatous lung disease", J IMMUNOL, 166(5), 2001, pp. 3432-3439

Abstract

Mice that had received adoptive transfer of DO11.10 TCR transgenic T cellspolarized toward a Th1 or a Th2 phenotype mere challenged with Ag-coated beads or with recombinant Mycobacterium tuberculosis expressing the OVA determinant. The resulting bead-induced pulmonary granulomas reflected the phenotype of the adoptively transferred T cells, with the Th2 cells promoting afibrotic reaction. Mice receiving Th1 cells mounted an epitope-specific protective response to challenge with recombinant M. tuberculosis. Th2 recipients were characterized by enhanced weight loss and lung fibrosis during acute high-dose infection. The combination of TCR transgenic T cells and epitope-tagged mycobacteria provides a novel experimental model for investigation of the pathogenesis of tuberculosis.

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Documento generato il 04/12/20 alle ore 18:42:25