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Titolo:
IL-7 administration alters the CD4 : CD8 ratio, increases T cell numbers, and increases T cell function in the absence of activation
Autore:
Geiselhart, LA; Humphries, CA; Gregorio, TA; Mou, S; Subleski, J; Komschlies, KL;
Indirizzi:
NCI, Frederick Canc Res & Dev Ctr, Sci Applicat Int Corp, Intramural Res Support Program, Frederick, MD 21702 USA NCI Frederick MD USA 21702 l Res Support Program, Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, Div Basic Sci, Expt Immunol Lab, Frederick, MD 21702 USA NCI Frederick MD USA 21702 Sci, Expt Immunol Lab, Frederick, MD 21702 USA
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 5, volume: 166, anno: 2001,
pagine: 3019 - 3027
SICI:
0022-1767(20010301)166:5<3019:IAATC:>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CORD-BLOOD; B-LINEAGE CELLS; GROWTH-FACTOR; HUMAN INTERLEUKIN-7; IN-VIVO; MICE; LYMPHOCYTES; PROLIFERATION; STIMULATION; LYMPHOPOIESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Komschlies, KL NCI, Frederick Canc Res & Dev Ctr, Sci Applicat Int Corp, Intramural Res Support Program, Bldg 560,Room 31-93, Frederick, MD 21702 USANCI Bldg 560,Room 31-93 Frederick MD USA 21702 MD 21702 USA
Citazione:
L.A. Geiselhart et al., "IL-7 administration alters the CD4 : CD8 ratio, increases T cell numbers, and increases T cell function in the absence of activation", J IMMUNOL, 166(5), 2001, pp. 3019-3027

Abstract

IL-7 is vital for the development of the immune system and profoundly enhances the function of mature T cells. Chronic administration of IL-7 to micemarkedly increases T cell numbers, especially CD8(+) T cells, and enhancesT cell functional potential, However, the mechanism by which these effectsoccur remains unclear. This report demonstrates that only 2 days of IL-7 treatment is needed for maximal enhancement of T cell function, as measured by proliferation, with a 6- to 12-fold increase in the proportion of CD4(+)and CD8(+) T cells in cell cycle by 18 h of ex vivo stimulation. Moreover,a 2-day administration of IL-7 in vivo increases basal proliferation by 4-and 14-fold in CD4(+) and CD8(+) T cells, respectively. These effects occur in the absence of cytokine production, increases in most activation markers, and changes in memory markers. This enhanced basal proliferation is thebasis for the increase in T cell numbers in that IL-7 induces an additional 60% and 85% of resting CD4(+) and CD8(+) T cells, respectively: to enter cell cycle in mice given IL-7 for 7 days. These results demonstrate that invivo administration of IL-7 increases T cell numbers and functional potential via a homeostatic, nonactivating process. These findings may suggest a unique clinical niche for IL-7 in that IL-7 therapy may increase T cell numbers and enhance responses to specific antigenic targets while avoiding a general, nonspecific activation of the T cell population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:48:27