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Titolo:
The hexapeptide KP-102 (D-Ala-D-B-Nal-Ala-Tip-D-Phe-Lys-NH2) stimulates growth hormone release in a cichlid fish (Oreochromis mossambicus)
Autore:
Shepherd, BS; Eckert, SM; Parhar, IS; Vijayan, MM; Wakabayashi, I; Hirano, T; Grau, EG; Chen, TT;
Indirizzi:
Univ Connecticut, Ctr Biotechnol, Storrs, CT 06269 USA Univ Connecticut Storrs CT USA 06269 Ctr Biotechnol, Storrs, CT 06269 USA Univ Kentucky, TH Morgan Sch Biol Sci, Lexington, KY 40506 USA Univ Kentucky Lexington KY USA 40506 ch Biol Sci, Lexington, KY 40506 USA Univ Hawaii, Hawaii Inst Marine Biol, Kaneohe, HI 96744 USA Univ Hawaii Kaneohe HI USA 96744 Inst Marine Biol, Kaneohe, HI 96744 USA Nippon Med Sch, Dept Physiol, Tokyo 113, Japan Nippon Med Sch Tokyo Japan 113 n Med Sch, Dept Physiol, Tokyo 113, Japan Univ Waterloo, Dept Biol, Waterloo, ON N2L 3G1, Canada Univ Waterloo Waterloo ON Canada N2L 3G1 ol, Waterloo, ON N2L 3G1, Canada Nippon Med Sch, Dept Med, Tokyo 113, Japan Nippon Med Sch Tokyo Japan 113 ippon Med Sch, Dept Med, Tokyo 113, Japan
Titolo Testata:
JOURNAL OF ENDOCRINOLOGY
fascicolo: 3, volume: 167, anno: 2000,
pagine: R7 - R10
SICI:
0022-0795(200012)167:3<R7:THK(SG>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
(GH)-RELEASING PEPTIDE; PITUITARY; TILAPIA; PROLACTINS; INVITRO; LOCALIZATION; RECEPTOR; TELEOST; ACTS; PAIR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Shepherd, BS Univ Connecticut, Ctr Biotechnol, Storrs, CT 06269 USA Univ Connecticut Storrs CT USA 06269 l, Storrs, CT 06269 USA
Citazione:
B.S. Shepherd et al., "The hexapeptide KP-102 (D-Ala-D-B-Nal-Ala-Tip-D-Phe-Lys-NH2) stimulates growth hormone release in a cichlid fish (Oreochromis mossambicus)", J ENDOCR, 167(3), 2000, pp. R7-R10

Abstract

Studies in mammals have shown that synthetic Met-enkephalin derivatives, called growth hormone-releasing peptides (GHRPs), stimulate growth hormone (GH) release. The present study was conducted to determine whether the GHRP,KP-102, specifically stimulates GH release in a teleost, Tilapia (Oreochromis mossambicus) were given a single intraperitoneal injection of KP-102 (D-Ala-D-B-Nal-Ala-Trp-D-Phe-Lys-NH2) or bovine GHRH(1-29)-amide or vehicle and blood was sampled at 1, 6 and 12 h after injection. KP-102 was administered at two doses of 1 ng/g and 10 ng/g body weight, whereas GHRH (positive control) was administered at a single dose of 10 ng/g body weight. Plasma levels of tilapia GH and prolactins (tPRL(177) and tPRL(188)) were determined by radioimmunoassay. As expected, GHRH injection significantly (P<0.001) elevated plasma GH levels (ng/ml) in tilapia at 6 h post-injection. KP-102 also significantly elevated GH levels (at the low dose) at 6 (P<0.05) and 12 (P<0.01) hours post-injection. There were no significant effects on plasma PRL(s) levels, although mean le, els of both PRLs were elevated at 6 h post-injection. These results show for the first time that GHRPs stimulate GHrelease in teleosts and suggest that the GHRP receptor and possibly a "Ghrelin-like" ligand are also present in lower vertebrates.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 03:02:21