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Titolo:
Maternal thyroid status regulates the expression of neuronal and astrocytic cytoskeletal proteins in the fetal brain
Autore:
Sampson, D; Pickard, MR; Sinha, AK; Evans, IM; Leonard, AJ; Ekins, RP;
Indirizzi:
Univ Coll London, Sch Med, Div Mol Endocrinol, London W1N 8AA, England Univ Coll London London England W1N 8AA ocrinol, London W1N 8AA, England
Titolo Testata:
JOURNAL OF ENDOCRINOLOGY
fascicolo: 3, volume: 167, anno: 2000,
pagine: 439 - 445
SICI:
0022-0795(200012)167:3<439:MTSRTE>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERMEDIATE FILAMENT PROTEIN; DEVELOPING RAT-BRAIN; ALPHA-INTERNEXIN; HORMONE; HYPOTHYROXINEMIA; PREGNANCY; WEIGHT; GLIA; GENE; HYPOTHYROIDISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Sinha, AK Univ Coll London, Sch Med, Div Mol Endocrinol, Mortimer St, London W1N 8AA, England Univ Coll London Mortimer St London England W1N 8AA AA, England
Citazione:
D. Sampson et al., "Maternal thyroid status regulates the expression of neuronal and astrocytic cytoskeletal proteins in the fetal brain", J ENDOCR, 167(3), 2000, pp. 439-445

Abstract

Maternal thyroid hormone (TH) crosses the placenta and is postulated to regulate fetal brain development. However, TH-dependent stages of fetal braindevelopment remain to be characterised. We have therefore compared the levels of several neuronal and glial cytoskeletal proteins in fetal brains from normal (N) and partially thyroidectomised (TX) rat dams by immunoblotting. Pregnancies were studied both before and after the onset of fetal TH secretion, which occurs at 17.5 days gestation (dg) in the rat. Maternal hypothyroidism disrupted fetal growth, so that fetal body and brain weights were reduced near term. Vimentin expression was unaffected, however, indicating normal acquisition of neuronal and glial precursor cells. Fetal brain levels of glial fibrillary acidic protein (GFAP) were reduced at21 dg, suggesting delayed astrocytic differentiation,, although regressionanalysis demonstrated appropriate GFAP levels for brain weight. Levels of alpha -internexin, the earliest neurofilament protein expressed in fetal brain were reduced at 16 dg in TX dams, but increased at 21 dg. The ontogeny of neurofilament-L was also perturbed in these pregnancies, with deficient levels apparent at both 16 and 21 dg. These effects on neuronal cytoskeletal proteins were unrelated to fetal brain growth retardation. These findings confirm that maternal hypothyroidism disrupts early fetal brain development. Early disturbances in neuronal differentiation are not corrected by the onset of fetal TH secretion. Such disturbances may contribute to the neurological damage observed in children born to hypothyroxinaemicmothers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:01:50