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Titolo:
Intracerebroventricular infusion of leptin elevates the secretion of luteinising hormone without affecting food intake in long-term food-restricted sheep, but increases growth hormone irrespective of bodyweight
Autore:
Henry, BA; Goding, JW; Tilbrook, AJ; Dunshea, FR; Clarke, IJ;
Indirizzi:
Prince Henrys Inst Med Res, Clayton, Vic 3168, Australia Prince Henrys Inst Med Res Clayton Vic Australia 3168 Vic 3168, Australia Monash Univ, Sch Med, Dept Pathol & Immunol, Prahran, Vic 3181, Australia Monash Univ Prahran Vic Australia 3181 unol, Prahran, Vic 3181, Australia Monash Univ, Dept Physiol, Clayton, Vic 3168, Australia Monash Univ Clayton Vic Australia 3168 siol, Clayton, Vic 3168, Australia Victorian Inst Anim Sci, Werribee, Vic 3030, Australia Victorian Inst AnimSci Werribee Vic Australia 3030 , Vic 3030, Australia
Titolo Testata:
JOURNAL OF ENDOCRINOLOGY
fascicolo: 1, volume: 168, anno: 2001,
pagine: 67 - 77
SICI:
0022-0795(200101)168:1<67:IIOLET>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELANIN-CONCENTRATING HORMONE; MESSENGER-RIBONUCLEIC-ACID; LUTEINIZING-HORMONE; OVARIECTOMIZED EWES; NEUROPEPTIDE-Y; LH-SECRETION; HYPOTHALAMIC NEUROPEPTIDES; GENE-EXPRESSION; PITUITARY-GLAND; GH SECRETION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Clarke, IJ Prince Henrys Inst Med Res, POB 5152, Clayton, Vic 3168, Australia Prince Henrys Inst Med Res POB 5152 Clayton Vic Australia 3168
Citazione:
B.A. Henry et al., "Intracerebroventricular infusion of leptin elevates the secretion of luteinising hormone without affecting food intake in long-term food-restricted sheep, but increases growth hormone irrespective of bodyweight", J ENDOCR, 168(1), 2001, pp. 67-77

Abstract

Leptin can act as a satiety factor and exert neuroendocrine effects, but most studies have been performed in fasted animals. We aimed to determine the effect of chronic under-nutrition on the response to a 3-day intracerebroventricular infusion of leptin with regard to food intake and the secretionof pituitary hormones. Ovariectomised ewes (n=6) had a mean (+/- S.E.M..) bodyweight of 56 +/- 0.8 kg on a diet available ad libitum (ad Iib) or 33.4+/- 1 kg on a restricted diet. The differential bodyweight was achieved bydietary means over a period of 6 months prior to the commencement of the study. Leptin (4 mug/h) or vehicle (artificial cerebrospinal fluid (aCSF)) was infused into the third cerebral ventricle for 3 days. Blood samples weretaken prior to commencement and on day 3 of infusion for the assay of plasma hormone levels. The experiment was repeated one week later in a crossover design. Food intake and metabolic status were monitored daily. The luteinising hormone (LH) pulse amplitude was lower (P<0.05) but plasma growth hormone (GH) levels were higher (P<0.05) in the food-restricted animals. Plasma levels of glucose, lactate, insulin, urea and triglycerides were similar in the two groups but nonesterified fatty acid levels were higher (P<0.01) in the animals on an ad Iib diet. Leptin reduced (P<0.05) food intake only in the animals fed an ad lib diet. Leptin increased (P<0.05) the secretion of LH in the food-restricted group only and increased (P<0.05) GH irrespective of bodyweight. In conclusion, leptin does not alter food intake in animals on a restricted diet but can increase the secretion of LH in the same animals. The treatment of leptin was not sufficient to reduce plasma GH levels in the food-restricted animals, suggesting that other factors or mechanisms must be involved in the regulation of this axis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:30:56