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Titolo:
Prevalence of Gs alpha mutations in Korean patients with pituitary adenomas
Autore:
Kim, HJ; Kim, MS; Park, YJ; Kim, SW; Park, DJ; Park, KS; Kim, SY; Cho, BY; Lee, HK; Jung, HW; Han, DH; Lee, HS; Chi, JG;
Indirizzi:
Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea Seoul Natl Univ Seoul South Korea 110744 Med, Seoul 110744, South Korea Seoul Natl Univ, Coll Med, Dept Pathol, Seoul 151, South Korea Seoul Natl Univ Seoul South Korea 151 ept Pathol, Seoul 151, South Korea Seoul Natl Univ Hosp, Clin Res Inst, Ctr Hormone Res, Seoul 110744, South Korea Seoul Natl Univ Hosp Seoul South Korea 110744 Seoul 110744, South Korea Seoul Natl Univ, Med Res Ctr, Inst Endocrinol Nutr & Metab, Seoul, South Korea Seoul Natl Univ Seoul South Korea inol Nutr & Metab, Seoul, South Korea Seoul Natl Univ, Coll Med, Dept Neurosurg, Seoul, South Korea Seoul Natl Univ Seoul South Korea d, Dept Neurosurg, Seoul, South Korea
Titolo Testata:
JOURNAL OF ENDOCRINOLOGY
fascicolo: 2, volume: 168, anno: 2001,
pagine: 221 - 226
SICI:
0022-0795(200102)168:2<221:POGAMI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN ENDOCRINE TUMORS; ACROMEGALIC PATIENTS; BIOCHEMICAL CHARACTERISTICS; SOMATOTROPH ADENOMAS; ADENYLYL CYCLASE; PROTEIN; HORMONE; GROWTH; CHAIN; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, SY Seoul Natl Univ, Coll Med, Dept Internal Med, 28 Yongon Dong, Seoul 110744, South Korea Seoul Natl Univ 28 Yongon Dong Seoul South Korea 110744 uth Korea
Citazione:
H.J. Kim et al., "Prevalence of Gs alpha mutations in Korean patients with pituitary adenomas", J ENDOCR, 168(2), 2001, pp. 221-226

Abstract

The reported frequencies of Gs alpha mutations (gsp mutations) in growth hormone (GH)-secreting pituitary adenomas are variable (ranging from 4.4 to 43%), and the presence of these mutations in the other pituitary adenomas is still a matter of controversy. Previous clinical and biochemical analystsof patients with GH-secreting pituitary adenomas and gsp mutations produced conflicting results and did not demonstrate obvious characteristics. Therefore, we investigated the prevalence of gsp mutations in Korean patients with pituitary adenomas and elucidated the characteristics of these patients. Forty-four GH-secreting adenomas, 7 prolactin (PRL)-secreting adenomas and 32 clinically non-functioning adenomas were examined for the presence of point mutations in codon 201 and 227 of the Gs alpha gene using a nested PCR and direct sequencing of DNA extracted from fresh tissue or paraffin-embedded pituitary adenoma samples. Seven of the 44 GH-secreting pituitary adenomas had point mutations at codon 201 or 227; of these, five mutations werein codon 201 and two were in codon 227. In patients with gsp mutations, mean tumor size was significantly smaller than in patients without gsp mutations (15.9 +/- 8.7 mm vs. 24.9 +/- 14.9 mm, P<0.05). Age, sex, basal GH levels, GH response to oral glucose loading, GH response to octreotide and surgical outcome were not different in the two groups. One of the 32 clinicallynon-functioning pituitary adenomas had a point mutation at codon 201; noneof the seven prolactinomas had these mutations, These results show that gsp mutations are not rare in Korean acromegalic patients and mean tumor sizeis significantly smaller in acromegalic patients with gsp mutations. Our results also confirm the low frequency of gsp mutations in clinically non-functioning pituitary adenomas and the absence of gsp mutations in prolactinoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 10:31:39