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Titolo:
Evidence of early onset of antidepressant effect in randomized controlled trials
Autore:
Stahl, SM; Nierenberg, AA; Gorman, JM;
Indirizzi:
Clin Neurosci Res Ctr, San Diego, CA 92122 USA Clin Neurosci Res Ctr San Diego CA USA 92122 Ctr, San Diego, CA 92122 USA Massachusetts Gen Hosp, Depress & Clin Res Program, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Program, Boston, MA 02114 USA New York State Psychiat Inst, Mental Hlth Res Ctr, New York, NY 10032 USA New York State Psychiat Inst New York NY USA 10032 New York, NY 10032 USA
Titolo Testata:
JOURNAL OF CLINICAL PSYCHIATRY
, volume: 62, anno: 2001, supplemento:, 4
pagine: 17 - 23
SICI:
0160-6689(2001)62:<17:EOEOOA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
MILD STRESS MODEL; MAJOR DEPRESSIVE DISORDER; PLACEBO-CONTROLLED TRIAL; TRUE DRUG RESPONSE; DOUBLE-BLIND; GENERAL-PRACTICE; PATTERN-ANALYSIS; VENLAFAXINE; CITALOPRAM; FLUOXETINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Stahl, SM Clin Neurosci Res Ctr, 8899 Univ Ctr Lane,Suite 130, San Diego, CA 92122 USA Clin Neurosci Res Ctr 8899 Univ Ctr Lane,Suite 130 San Diego CA USA 92122
Citazione:
S.M. Stahl et al., "Evidence of early onset of antidepressant effect in randomized controlled trials", J CLIN PSY, 62, 2001, pp. 17-23

Abstract

Although antidepressant medications are effective in approximately 70% of patients with major depressive disorder, they have a delayed onset of therapeutic effect. This latency is problematic in that it prolongs the impairments associated with depression, leaves patients vulnerable to an increased risk of suicide, increases the likelihood that a patient will prematurely discontinue therapy, and increases medical costs associated with severe depression. No adequately designed prospective trials have been conducted to evaluate comparative time to onset of antidepressant effect. However, evidence suggests that some antidepressant agents may begin to work faster than others. Citalopram, venlafaxine, and mirtazapine each have exhibited statistically significant differences in some measures of antidepressant action within the first 2 weeks of treatment, both in placebo-controlled trials and in head-to-head comparisons with other antidepressants. This article reviewsthe data that hint at these drug-specific differences in time to onset of action. Given the potential benefits of early-acting antidepressant treatments, the possibility of superior speed of onset of citalopram venlafaxine, and mirtazapine presented here merits further study in adequately designed,prospective clinical trials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:50:51