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Titolo:
The effect of the eradication of Helicobacter pylori infection on hemorrhage because of duodenal ulcer
Autore:
Pellicano, R; Peyre, S; Leone, N; Repici, A; De Angelis, C; Rizzi, R; Rizzetto, M; Ponzetto, A;
Indirizzi:
Univ Turin, Dept Internal Med, Turin, Italy Univ Turin Turin ItalyUniv Turin, Dept Internal Med, Turin, Italy Cuorgne Hosp, UOA Gastroenterol, Cuorgne, Italy Cuorgne Hosp Cuorgne Italy rgne Hosp, UOA Gastroenterol, Cuorgne, Italy Molinette Mauriziano Hosp, Dept Gastroenterol, I-10126 Turin, Italy Molinette Mauriziano Hosp Turin Italy I-10126 erol, I-10126 Turin, Italy
Titolo Testata:
JOURNAL OF CLINICAL GASTROENTEROLOGY
fascicolo: 3, volume: 32, anno: 2001,
pagine: 222 - 224
SICI:
0192-0790(200103)32:3<222:TEOTEO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
THERAPY; DISEASE; PREVENTION;
Keywords:
Helicobacter pylori; duodenal ulcer; bleeding; eradication;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Pellicano, R Ambulatorio Gastroenterol, Via Chiabrera 34,3 Piano, I-10126 Turin, Italy Ambulatorio Gastroenterol Via Chiabrera 34,3 Piano Turin Italy I-10126
Citazione:
R. Pellicano et al., "The effect of the eradication of Helicobacter pylori infection on hemorrhage because of duodenal ulcer", J CLIN GAST, 32(3), 2001, pp. 222-224

Abstract

The cost of a recurrently bleeding duodenal ulcer (DU) is very high, both from a human and an economic point-of-view. Helicobacter pylori infection plays an important role in the pathogenesis of DU disease and its complications, such as bleeding. Curl of H. pylori infection is recommended in patients with DU and its complications, although in the latter case. the most efficient management is not yet a defined issue. In particular, acid secretioninhibitors may nor contribute to long-term cure. Our aims were to ascertain whether the recurrence of bleeding because of DU could be prevented by H.pylori eradication and whether lone-term inhibition of gastric acid outputis needed to prevent recurrence. Eighty-four patients (65 men; mean age, 55.1 years), who had bled because of recurrent DU, were followed after the cure of H. pylori infection. None of the patients were on therapy with nonsteroidal antiinflammatory drugs. Successful cure of H. pylori was determinedby gastroscopy, histology, and serology performed at 3, 6, 12, 24, and 48 months after the eradication treatment. A C-13 urea breath rest was performed when the results of serology were unclear and also at recurrence of DU or bleeding. After the antibiotic treatment, 16 patients stopped all medications, whereas 38 continued long-term therapy with histamine type 2 receptorantagonists. During a mean follow-up period of 47.2 months (range, 37-65 months), recurrence of DU at endoscopy was observed in three patients in each group (p = 0.56), but none bled again. We conclude that H. pylori eradication prevents DU recurrence and rebleeding, that reinfection rate by H. pylori after cure was nil at 4 years, and that lone-term inhibition of acid secretion may not improve outcome after cure of H. pylori, even in patients whose DU was complicated by hemorrhage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 15:14:44