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Titolo:
White blood cell count: An independent predictor of coronary heart diseasemortality among a national cohort
Autore:
Brown, DW; Giles, WH; Croft, JB;
Indirizzi:
Ctr Dis Control & Prevent, Cardiovasc Hlth Branch, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA Ctr Dis Control & Prevent Atlanta GA USA 30341 mot, Atlanta, GA 30341 USA
Titolo Testata:
JOURNAL OF CLINICAL EPIDEMIOLOGY
fascicolo: 3, volume: 54, anno: 2001,
pagine: 316 - 322
SICI:
0895-4356(200103)54:3<316:WBCCAI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; ALL-CAUSE MORTALITY; LEUKOCYTE COUNT; ARTERY DISEASE; RISK-FACTORS; DEATH INDEX; PLAQUE RUPTURE; FOLLOW-UP; ATHEROSCLEROSIS; INFLAMMATION;
Keywords:
white blood cell count; coronary heart disease; mortality; survival analysis; epidemiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Giles, WH Ctr Dis Control & Prevent, Cardiovasc Hlth Branch, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE, Atlanta, GA 30341 USA Ctr Dis Control & Prevent 4770 Buford Highway NE Atlanta GA USA 30341
Citazione:
D.W. Brown et al., "White blood cell count: An independent predictor of coronary heart diseasemortality among a national cohort", J CLIN EPID, 54(3), 2001, pp. 316-322

Abstract

An association between elevated white blood cell (WBC) count and coronary heart disease (CHD) mortality has been previously observed. However, the relationship between WBC count and CHD mortality independent of cigarette smoking and the possible interaction between WBC count and smoking remains unclear. We examined the association between WBC count and CHD mortality with Cox regression analyses of data from 8914 adults, aged 30-75, in the NHANESII Mortality Study (1976-1992). Covariates included age, sex, race, education, physical activity, smoking status, hypertensive status, total serum cholesterol, body mass index, hematocrit, and history of cardiovascular disease, stroke, and diabetes. During 17 follow-up years, there were 548 deaths from CHD (ICD-9 410-414) and 782 deaths from diseases of the heart (ICD-9 390-398, 402, 404, 410-414, 415-417, 420-429). Mean WBC count (x10(9) cells/L) was greater among persons who died from CHD (7.6 vs 7.2, P < .001). Compared to persons with a WBC count <6.1, persons with a WBC count > 7.6 were at increased risk of death from CHD (relative risk = 1.4, 95% confidence interval = 1.1-1.8) after adjustment for smoking status and other CVD risk factors. Similar results were observed among nonsmokers (RR = 1.4, 95% CI = 0.9-2.0). These results suggest that higher WBC counts are a predictor of CHD mortality independent of the effects of smoking and other traditional CVDrisk factors, which may indicate a role for inflammation in the pathogenesis of CHD. Additional studies are needed to determine whether interventionsto decrease inflammation can reduce the risk for CHD associated with elevated WBC. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 07/07/20 alle ore 22:20:55