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Titolo:
Application of ion-exchange cartridge clean-up in food analysis IV. Confirmatory assay of benzylpenicillin, phenoxymethylpenicillin, oxacillin, cloxacillin, nafcillin and dicloxacillin in bovine tissues by liquid chromatography-electrospray ionization tandem mass spectrometry
Autore:
Ito, Y; Ikai, Y; Oka, H; Matsumoto, H; Miyazaki, Y; Takeba, K; Nagase, H;
Indirizzi:
Aichi Prefectural Inst Publ Hlth, Kita Ku, Nagoya, Aichi 4628576, Japan Aichi Prefectural Inst Publ Hlth Nagoya Aichi Japan 4628576 628576, Japan Tokyo Metropolitan Res Lab Publ Hlth, Shinjuku Ku, Tokyo 1690073, Japan Tokyo Metropolitan Res Lab Publ Hlth Tokyo Japan 1690073 1690073, Japan Gifu Pharmaceut Univ, Gifu 5028585, Japan Gifu Pharmaceut Univ Gifu Japan 5028585 maceut Univ, Gifu 5028585, Japan
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY A
fascicolo: 2, volume: 911, anno: 2001,
pagine: 217 - 223
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-LACTAM ANTIBIOTICS; ULTRAVIOLET DETECTION; PENICILLIN-G; MILK; KIDNEY; RESIDUES; MUSCLE; LIVER;
Keywords:
food analysis; benzylpenicillin; phenoxymethylpenicillin; oxacillin; cloxacillin; nafcillin; dicloxacillin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Ito, Y Aichi Prefectural Inst Publ Hlth, Kita Ku, 7-6 Nagare, Nagoya, Aichi 4628576, Japan Aichi Prefectural Inst Publ Hlth 7-6 Nagare Nagoya Aichi Japan 4628576
Citazione:
Y. Ito et al., "Application of ion-exchange cartridge clean-up in food analysis IV. Confirmatory assay of benzylpenicillin, phenoxymethylpenicillin, oxacillin, cloxacillin, nafcillin and dicloxacillin in bovine tissues by liquid chromatography-electrospray ionization tandem mass spectrometry", J CHROMAT A, 911(2), 2001, pp. 217-223

Abstract

A multiresidue analytical method was developed for the confirmation of benzylpenicillin (PCG), phenoxymethylpenicillin (PCV), oxacillin (MPIPC), cloxacillin (MCIPC), nafcillin (NFPC) and dicloxacillin (MDIPC) in bovine tissues using electrospray ionization liquid chromatography-tandem mass spectrometry (LC-ESI-MS-MS) with a product ion scan mode. All penicillins gave [M-H](-), [M-K-CO2](-) and [M-H-141](-) as the product ion, when [M-H](-) was selected as the precursor ion. Combination of an ion-exchange cartridge clean-up and the LC-ESI-MS-MS method can reliably identify all of these penicillins fortified at a concentration of 0.05 mg/kg in bovine tissues, including liver, kidney and muscle. The limits of confirmation satisfy the maximum residue limits for each of the penicillins established by the World Health Organization, US Food and Drug Administration, European Union and Japan. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:25:52