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Titolo:
Effect of ketoconazole, itraconazole and fluconazole on the gastrointestinal colonization of mice by Candida albicans
Autore:
Samonis, G; Maraki, S; Hajiioannou, I; Chatzinikolaou, I; Rolston, KVI; Bodey, GP; Kontoyiannis, DP;
Indirizzi:
Univ Crete, Div Med, Heraklion 71110, Crete, Greece Univ Crete Heraklion Crete Greece 71110 d, Heraklion 71110, Crete, Greece
Titolo Testata:
JOURNAL OF CHEMOTHERAPY
fascicolo: 1, volume: 13, anno: 2001,
pagine: 66 - 69
SICI:
1120-009X(200102)13:1<66:EOKIAF>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER-PATIENTS; FUNGAL-INFECTIONS; ORAL FLUCONAZOLE; PREVENTION; PROPHYLAXIS; TRIAL; TRANSPLANTATION; NYSTATIN;
Keywords:
gastrointestinal tract; mice; Candida albicans; ketoconazole; itraconazole; fluconazole;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Samonis, G Univ Crete, Div Med, POB 1393, Heraklion 71110, Crete, Greece Univ Crete POB 1393 Heraklion Crete Greece 71110 Crete, Greece
Citazione:
G. Samonis et al., "Effect of ketoconazole, itraconazole and fluconazole on the gastrointestinal colonization of mice by Candida albicans", J CHEMOTHER, 13(1), 2001, pp. 66-69

Abstract

Cr1:CD1 (ICR) BR mice were colonized in the gastrointestinal (GI) tract with Candida albicans. This strain was susceptible to ketoconazole (MIC=0.25 mug/ml), itraconazole (minimum inhibitory concentration, MIC=0.25 mug/ml), and fluconazole (MIC=4 mug/ml). Subsequently the animals received monotherapy with ketoconazole by mouth (equivalent to human dose of 2.9 mg/kg/day), or itraconazole by mouth (equivalent to human dose of 2.9 mg/kg/day), or fluconazole either subcutaneously (equivalent to human dose of 2.2 mg/kg/day), or by mouth (equivalent to human dose of 2.2 mg/kg/day), for 10 days. Quantitative stool cultures at the end and one week after the end of treatmentrevealed that all three azoles caused a small and statistically non significant reduction of C. albicans concentration in the stools. The different route of administration of fluconazole did not produce different results. Inconclusion, these azoles, used at the present doses and schedules, have minimal effect on murine GI colonization by this strain of C. albicans which is susceptible but with rather increased MICs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 20:59:07