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Titolo:
Ontogeny of the dopamine D-2 receptor mRNA expressing cells in the human hippocampal formation and temporal neocortex
Autore:
Gurevich, EV; Kordower, JH; Joyce, JN;
Indirizzi:
Thomas H Christopher Ctr Parkinsons Dis Res Ctr, Sun Hlth Res Inst, Sun City, AZ 85351 USA Thomas H Christopher Ctr Parkinsons Dis Res Ctr Sun City AZ USA 85351 USA Rush Presbyterian St Lukes Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USARush Presbyterian St Lukes Med Ctr Chicago IL USA 60612 ago, IL 60612 USA
Titolo Testata:
JOURNAL OF CHEMICAL NEUROANATOMY
fascicolo: 3-4, volume: 20, anno: 2000,
pagine: 307 - 325
SICI:
0891-0618(200012)20:3-4<307:OOTDDR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAJAL-RETZIUS CELLS; HYDROXYLASE-IMMUNOREACTIVE FIBERS; POSTNATAL MURINE HIPPOCAMPUS; YM09151-2 BINDING-SITES; HUMAN ENTORHINAL CORTEX; FETAL RHESUS-MONKEY; TYROSINE-HYDROXYLASE; CEREBRAL-CORTEX; MESSENGER-RNA; HUMAN BRAIN;
Keywords:
ammonic subfields; subiculum; dentate gyrus; Cajal-Retzius cells; cortical plate; marginal zone; fetal human brain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Joyce, JN Thomas H Christopher Ctr Parkinsons Dis Res Ctr, Sun Hlth Res Inst, 10515 W Santa Fe Dr, Sun City, AZ 85351 USA Thomas H Christopher Ctr Parkinsons Dis Res Ctr 10515 W Santa Fe Dr Sun City AZ USA 85351
Citazione:
E.V. Gurevich et al., "Ontogeny of the dopamine D-2 receptor mRNA expressing cells in the human hippocampal formation and temporal neocortex", J CHEM NEUR, 20(3-4), 2000, pp. 307-325

Abstract

The study details the cellular expression of the dopamine D-2 receptor mRNA in the human temporal lobe during prenatal development. At 13 embryonic weeks (E13) D-2 mRNA was widely expressed in the temporal lobe. At this timepoint in the dentate gyrus D-2 mRNA positive cells first appeared at the outer border of the granular layer and their number increased with development. The CA1 exhibited the highest level of D-2 mRNA expression. By E19-25 the hippocampal formation underwent rapid morphological maturation. D-2 mRNAexpression became more uniform and dense in the ammonic subfield. At all ages the subiculum appeared more mature morphologically but less intensely stained for D-2 mRNA than the ammonic fields. In the entorhinal cortex D-2 mRNA expression was most conspicuous in the future layer II at all ages. In the temporal neocortex D-2 mRNA-positive cells were detected in the subplate and cortical plate. Differentiation of the cortical plate was accompaniedby concentration of D-2 mRNA-positive cells in layer V. The most conspicuous cells expressing D-2 mRNA were found in the marginal zone of all regionsand resembled Cajal-Retzius cells in morphology and location. Density of putative Cajal-Retzius cells expressing D-2 mRNA decreased with development. They all but disappeared from the hippocampal areas by mid gestation, but in the temporal neocortex occasional cells were seen even at term. Early and widespread but region and cell type specific expression of D-2 receptor mRNA suggests an important role of this DA receptor subtype in prenatal development of the human temporal lobe. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:27:22