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Titolo:
Distribution of DARPP-32 immunoreactive structures in the quail brain: anatomical relationship with dopamine and aromatase
Autore:
Absil, P; Foidart, A; Hemmings, HC; Steinbusch, HWM; Ball, GF; Balthazart, J;
Indirizzi:
Univ Liege, Ctr Res Cellular & Mol Neurobiol, Res Grp Behav Neuroendocrinol, B-4020 Liege, Belgium Univ Liege Liege Belgium B-4020 v Neuroendocrinol, B-4020 Liege, Belgium Cornell Univ, Dept Anesthesiol, New York, NY USA Cornell Univ New York NYUSA ll Univ, Dept Anesthesiol, New York, NY USA Maastricht Univ, Dept Psychiat, Maastricht, Netherlands Maastricht Univ Maastricht Netherlands sychiat, Maastricht, Netherlands Maastricht Univ, Div Neuropsychol, Maastricht, Netherlands Maastricht Univ Maastricht Netherlands psychol, Maastricht, Netherlands Johns Hopkins Univ, Dept Psychol, Behav Neuroendocrinol Grp, Baltimore, MD21218 USA Johns Hopkins Univ Baltimore MD USA 21218 nol Grp, Baltimore, MD21218 USA
Titolo Testata:
JOURNAL OF CHEMICAL NEUROANATOMY
fascicolo: 1, volume: 21, anno: 2001,
pagine: 23 - 39
SICI:
0891-0618(200101)21:1<23:DODISI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENOSINE 3'-5'-MONOPHOSPHATE-REGULATED PHOSPHOPROTEIN; MALE SEXUAL-BEHAVIOR; JAPANESE-QUAIL; TYROSINE-HYDROXYLASE; IMMUNOCYTOCHEMICAL LOCALIZATION; NEUROANATOMICAL SPECIFICITY; REGULATED PHOSPHOPROTEIN; CHICKEN HYPOTHALAMUS; COTURNIX JAPONICA; GALLUS-DOMESTICUS;
Keywords:
dopaminoceptive cells; tyrosine hydroxylase; estrogen synthase; aromatase activity; preoptic area; nucleus striae terminalis; dopamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
80
Recensione:
Indirizzi per estratti:
Indirizzo: Balthazart, J Univ Liege, Ctr Res Cellular & Mol Neurobiol, Res Grp Behav Neuroendocrinol, 17 Pl Delcour,Bat L1, B-4020 Liege, Belgium Univ Liege 17 Pl Delcour,Bat L1 Liege Belgium B-4020 elgium
Citazione:
P. Absil et al., "Distribution of DARPP-32 immunoreactive structures in the quail brain: anatomical relationship with dopamine and aromatase", J CHEM NEUR, 21(1), 2001, pp. 23-39

Abstract

We recently demonstrated that dopamine (DA) as well as different DA receptor agonists and antagonists are able to decrease within a few minutes the aromatase activity (AA) measured in vitro in homogenates or in explants of the quail preoptic area hypothalamus. In addition, DA also appears to regulate AA, in vivo presumably by modifying enzyme synthesis. The cellular mechanisms and the anatomical substrate that mediate these controls of AA by DA are poorly understood. Tyrosine hydroxylase-immunoreactive (TH-ir) fibers and punctate structures have been previously observed in close vicinity of aromatase-immunoreactive (ARO-ir) cells in the quail medial preoptic nucleus(POM) and bed nucleus striae terminalis (BST) but these fibers could reflect a noradrenergic innervation. We also do not know whether aromatase cellsare dopaminoceptive. The main goal of the present study was therefore to bring more information on the anatomical relationships between aromatase expressing neurons and the dopaminergic system in the quail brain. The visualization by immunocytochemistry of DA and of the D1 receptor associated protein DARPP-32 was used to address these questions. DA-ir fibers were observedin the quail forebrain and overlapped extensively with nuclei that containhigh densities of ARO-ir cells such as the POM and BST. This confirms thatthe previously reported TH-ir innervation of ARO-ir cells is, at least in part, of dopaminergic nature. DARPP-32-immunoreactive cells were found in periventricular position throughout the hypothalamus. DARPP-32-ir cells werealso observed in telencephalic and mesencephalic areas (hyperstriatum accessorium, paleostriatum, nucleus intercollicularis, optic tectum). DARPP-32-ir fibers were widespread in tel-, di-, and mes-encephalic areas. The highest densities of immunoreactive fibers were detected in the lobus parolfactorius, paleostriatum augmentatum and substantia nigra/area ventralis of Tsai. In double-labeled sections, appositions between DARPP-32 fibers and ARO-ir cells were present in the dorsolateral POM and BST but DARPP-32 immunoreactivity was not detected in the ARO-ir perikarya (no colocalization). Thesedata confirm the presence of a dopaminoceptive structures within the main cell clusters of ARO-ir cells in the quail brain but provide no evidence that these ARO-ir cells are themselves dopaminoceptive. Because DARPP-32 is not present in all types of cells expressing DA receptors, the presence of DA receptors that would not be associated with DARPP-32 in ARO-ir cells still remains to be investigated (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 25/01/20 alle ore 18:32:13