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Titolo:
Effects of inhaled prostacyclin analogue on chronic hypoxic pulmonary hypertension
Autore:
Abe, Y; Tatsumi, K; Sugito, K; Ikeda, Y; Kimura, H; Kuriyama, T;
Indirizzi:
Chiba Univ, Sch Med, Dept Chest Med, Chuou Ku, Chiba 2608670, Japan Chiba Univ Chiba Japan 2608670 Chest Med, Chuou Ku, Chiba 2608670, Japan
Titolo Testata:
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
fascicolo: 3, volume: 37, anno: 2001,
pagine: 239 - 251
SICI:
0160-2446(200103)37:3<239:EOIPAO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; NITRIC-OXIDE; ADENYLATE-CYCLASE; VASOCONSTRICTION; PGI2; LUNGS; PROSTAGLANDIN; AEROSOL; SHEEP; RATS;
Keywords:
hypoxic pulmonary vasoconstriction; prostacyclin; prostacyclin receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Abe, Y Chiba Univ, Sch Med, Dept Chest Med, Chuou Ku, 1-8-1 Inohana, Chiba2608670, Japan Chiba Univ 1-8-1 Inohana Chiba Japan 2608670 Chiba 2608670, Japan
Citazione:
Y. Abe et al., "Effects of inhaled prostacyclin analogue on chronic hypoxic pulmonary hypertension", J CARDIO PH, 37(3), 2001, pp. 239-251

Abstract

Inhaled PGI(2) has been reported to elicit pulmonary vasodilation, but whether it is also effective in treating chronic hypoxic pulmonary hypertension is still uncertain. We designed this study to address the in vivo effectiveness of inhaled Beraprost, a stable PGI(2) analogue, on pulmonary vascular tone during hypoxic exposure in normoxic (N) and chronically hypoxic (CH)rats. Pulmonary vasodilation was observed by low-dose inhaled Beraprost inN rats, but not in CH rats. It was not until higher doses of Beraprost were given that pulmonary vasodilation was obtained in CH rats. When the agentwas continuously administered by an intravascular route at the inhaled dose, it elicited no vasodilation in N rats. On the contrary, it elicited profound vasodilation in CH rats, although a concomitant systemic hypotension was observed. The PGI(2) receptor mRNA expression was unchanged in the lungsof CH rats compared with that of N rats. We conclude that low doses of aerosolized Beraprost may reduce pulmonary vascular tone in rats without preexisting lung diseases. In contrast, when hypoxic pulmonary hypertension is present, the threshold of Beraprost inhalation was elevated to provoke pulmonary vasodilation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:25:00