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Titolo:
The effects of fenoldopam on coronary conduit blood flow after coronary artery bypass graft surgery
Autore:
Halpenny, M; Lakshmi, S; ODonnell, A; OCallaghan-Enright, S; OConnell, D; Shorten, G;
Indirizzi:
Cork Univ Hosp, Dept Anesthesia, Cork, Ireland Cork Univ Hosp Cork Ireland k Univ Hosp, Dept Anesthesia, Cork, Ireland Cork Univ Hosp, Dept Intens Care Med, Cork, Ireland Cork Univ Hosp Cork Ireland v Hosp, Dept Intens Care Med, Cork, Ireland Cork Univ Hosp, Dept Surg, Cork, Ireland Cork Univ Hosp Cork IrelandCork Univ Hosp, Dept Surg, Cork, Ireland
Titolo Testata:
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
fascicolo: 1, volume: 15, anno: 2001,
pagine: 72 - 76
SICI:
1053-0770(200102)15:1<72:TEOFOC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERNAL MAMMARY ARTERY; SAPHENOUS-VEIN GRAFTS; RECEPTOR AGONIST; DOPAMINE; REVASCULARIZATION; HEMODYNAMICS; HEART; DOG;
Keywords:
coronary artery bypass; dopamine receptors; fenoldopam; internal mammary artery; saphenous vein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Halpenny, M 3 Waltham,Clonfadda Wood,Mt Merrion Ave, Dublin, Ireland 3 Waltham,Clonfadda Wood,Mt Merrion Ave Dublin Ireland land
Citazione:
M. Halpenny et al., "The effects of fenoldopam on coronary conduit blood flow after coronary artery bypass graft surgery", J CARDIOTHO, 15(1), 2001, pp. 72-76

Abstract

Objective: To quantify the effects of fenoldopam, 0.1 mug/ kg/min, on leftinternal mammary artery (LIMA) and saphenous vein blood flow after coronary anastomosis. Design: Prospective, randomized, double-blind, placebo-controlled trial. Setting: University teaching hospital, single institution. Participants: Thirty-one American Society of Anesthesiologists III patients undergoing elective coronary revascularization. Interventions: A perivascular ultrasonic flow probe (Linton Instrumentation, Norfolk, UK) was placed around the LIMA and saphenous vein graft after coronary anastomosis. Measurements and Main Results: Immediately before and at 5-minute intervals for 15 minutes after starting the infusion, blood flow was measured in the LIMA and one saphenous vein graft using a transit time ultrasonic flow probe. Heart rate, blood pressure, and central venous pressure were documented at these time points. Administration of fenoldopam, 0.1 mug/kg/min, did not alter heart rate or blood pressure. A small, nonsignificant increase in LIMA blood flow occurred during the 15-minute study period (30 +/- 12 to 35+/- 10 mL/min) in patients who received fenoldopam. No significant changesoccurred in the placebo group. Conclusions: The findings indicate that fenoldopam, 0.1 mug/kg/min, did not influence coronary conduit blood flow to a clinically significant extent. The small increase in LIMA blood flow may be of greater importance in high-risk patients or in the prevention of coronary arterial spasm. Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 09:00:09