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Titolo:
The effects of recent aspirin ingestion on platelet function in cardiac surgical patients
Autore:
Gibbs, NM; Weightman, WM; Thackray, NM; Michalopoulos, N; Weidmann, C;
Indirizzi:
Sir Charles Gairdner Hosp, Dept Anaesthesia, Nedlands, WA 6009, Australia Sir Charles Gairdner Hosp Nedlands WA Australia 6009 , WA 6009, Australia PathCtr, Nedlands, WA, Australia PathCtr Nedlands WA AustraliaPathCtr, Nedlands, WA, Australia
Titolo Testata:
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
fascicolo: 1, volume: 15, anno: 2001,
pagine: 55 - 59
SICI:
1053-0770(200102)15:1<55:TEORAI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTOPERATIVE BLOOD-LOSS; TRANSFUSION REQUIREMENTS; PFA-100(TM) SYSTEM; BYPASS; SURGERY; TRIAL;
Keywords:
aspirin; blood platelets; platelet function; surgery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Gibbs, NM Sir Charles Gairdner Hosp, Dept Anaesthesia, Nedlands, WA 6009, Australia Sir Charles Gairdner Hosp Nedlands WA Australia 6009 Australia
Citazione:
N.M. Gibbs et al., "The effects of recent aspirin ingestion on platelet function in cardiac surgical patients", J CARDIOTHO, 15(1), 2001, pp. 55-59

Abstract

Objective: To examine the effects of the preoperative aspirin-free interval on platelet function in cardiac surgical patients. Design: Prospective clinical investigation. Setting: University-affiliate teaching hospital. Participants: Patients undergoing elective coronary artery bypass graft surgery (n = 100). Interventions: The patients were divided into 3 groups based on the numberof days since they last ingested aspirin: less than or equal to2 days, 3 to 7 days, and >7 days. Preoperative platelet function was assessed in all patients using platelet aggregation responses to arachidonic acid, 5 mug/mL,and Platelet Function Analyser (PFA100) collagen/epinephrine closure times. Measurements and Main Results: Patients who ceased aspirin less than or equal to2 days preoperatively had weaker platelet aggregation responses (18.5% +/- 7% maximum aggregation, mean +/- SD, n = 36) than patients who ceasedaspirin 3 to 7 days preoperatively (68.8% +/- 29%, n = 48, p < 0.001) or >7 days preoperatively (68.3% +/- 28%, n = 16, p < 0.001). Similarly, patients who ceased aspirin <less than or equal to>2 days preoperatively had longer PFA100 closure times (168 +/- 52 sec) than patients who ceased aspirin 3to 7 days preoperatively (122 +/- 43 sec, p < 0.001) or >7 days preoperatively (128 +/- 42 sec, p < 0.01). The percentage of abnormal responses was also greatest in the aspirin <less than or equal to>2 days group. Conclusion: Cardiac surgical patients who ingest aspirin less than or equal to2 days preoperatively have greater impairment of platelet function thanpatients who have a longer preoperative aspirin-free interval. Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:20:20