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Titolo:
Platelet glass bead retention predicts bleeding after cardiac surgery
Autore:
Ereth, MH; Nuttall, GA; Ericson, DG; Cooney, WP; Fisher, BR; Oliver, WC; Schaff, HV; Fass, DN;
Indirizzi:
Mayo Clin & Mayo Fdn, Dept Anesthesiol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 siol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Dept Biochem & Mol Biol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Biol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Dept Cardiovasc Surg, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Surg, Rochester, MN 55905 USA
Titolo Testata:
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
fascicolo: 1, volume: 15, anno: 2001,
pagine: 49 - 54
SICI:
1053-0770(200102)15:1<49:PGBRPB>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERY BYPASS-SURGERY; CARDIOPULMONARY BYPASS; BLOOD-LOSS; TRANSFUSION; HEMOSTASIS; COAGULATION; DYSFUNCTION; ACTIVATION; FIBRINOLYSIS; AGGREGATION;
Keywords:
cardiopulmonary bypass; monitoring; coagulation; platelet function; laboratory analysis; platelet retention; cardiac surgery; transfusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Ereth, MH Mayo Clin & Mayo Fdn, Dept Anesthesiol, 200 1st St SW, Rochester, MN 55905USA Mayo Clin & Mayo Fdn 200 1st St SW Rochester MN USA 55905 905USA
Citazione:
M.H. Ereth et al., "Platelet glass bead retention predicts bleeding after cardiac surgery", J CARDIOTHO, 15(1), 2001, pp. 49-54

Abstract

Objective: To determine if the platelet glass bead retention assay can predict bleeding after cardiac surgery. Design: Prospective, observational study. Setting: Large, tertiary care, academic medical center. Participants: Forty-three adult patients scheduled to undergo elective cardiac surgery employing cardiopulmonary bypass (CPB). Measurements and Main Results: Whole blood samples were observed for platelet count, prothrombin time, and platelet (glass bead) retention assay. Theplatelet retention and prothrombin times were independent univariant and multivariant predictors of bleeding after CPB (r = 0.554, p = 0.0002 and r =0.655, p = 0.00001). Conclusion: The platelet glass bead retention assay measures dynamic platelet function and is sensitive to the CPB-induced adhesion and aggregation defect and correlates with postoperative blood loss. Modification of this platelet function assay used with the prothrombin time may provide a simple and effective diagnostic approach to bleeding after CPB. Copyright (C) 2001 by W.B. Saunders Company.

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Documento generato il 19/01/20 alle ore 12:16:11