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Titolo:
Blood S-100 protein concentration in children undergoing cardiac surgery
Autore:
Camci, E; Tugrul, M; Korkut, K; Tireli, E;
Indirizzi:
Univ Istanbul, Istanbul Med Fac, Dept Anesthesiol & Cardiovasc Surg, Istanbul, Turkey Univ Istanbul Istanbul Turkey esiol & Cardiovasc Surg, Istanbul, Turkey
Titolo Testata:
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
fascicolo: 1, volume: 15, anno: 2001,
pagine: 29 - 34
SICI:
1053-0770(200102)15:1<29:BSPCIC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPOTHERMIC CIRCULATORY ARREST; CORONARY-BYPASS SURGERY; NEURON-SPECIFIC ENOLASE; CARDIOPULMONARY BYPASS; CEREBRAL COMPLICATIONS; HEART-SURGERY; SERUM; FLOW; OPERATIONS; DYSFUNCTION;
Keywords:
cerebral injury; S-100; cardiac surgery; children; cardiopulmonary bypass; acid-base balance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Tugrul, M IU Istanbul Tip Fak Anesteziyoloji AD, Capa Klin, TR-34390 Istanbul, Turkey IU Istanbul Tip Fak Anesteziyoloji AD Istanbul Turkey TR-34390
Citazione:
E. Camci et al., "Blood S-100 protein concentration in children undergoing cardiac surgery", J CARDIOTHO, 15(1), 2001, pp. 29-34

Abstract

Objectives: To investigate plasma levels of the pp isomer of S-100 proteinand to assess the relationship between post-cardiopulmonary bypass (CPB) levels of this marker and a variety of perioperative and patient factors in children undergoing cardiac surgery. Design: Prospective study. Setting: University hospital. Participants: Twenty-five children. Interventions: Blood samples (2 mL) for S-100 determinations were collected after the induction of anesthesia, 30 minutes after aortic cross-clamping, 1 hour after the termination of CPB, and 5 and 24 hours after the operation. Electroencephalogram activity was recorded, and neurologic examination was performed on all children 1 day before and 10 days after the operation. Lowest values of nasopharyngeal temperature, mean arterial pressure, arterial carbon dioxide tension (PaCO2), pH, and hematocrit during CPB were recorded. Measurements and Main Results: The overall change in S-100 during the study period was found to be statistically significant (p < 0.0001). correlation between <Delta>S-100 and age (r = -0.45; p = 0.04), body surface area (r = -0.63; p 0.002), nasopharyngeal temperature (r = -0.55; p = 0.01), and PaCO2 (r = -0.55; p = 0.009) was statistically significant in infants and children. Multivariate regression analysis indicated significant effects of PaCO2 and body surface area on DeltaS-100 levels and area under the curve values. Conclusion: In contrast to newborns, infants and older children showed prominent increases in S-100 protein concentration. Lack of pathologic electroencephalogram findings and neurologic signs in the postoperative period precludes the clinical use of S-100 protein concentration as a sensitive marker of cerebral injury. Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:24:10