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Titolo:
Diagnosis and therapy of sporadic and familial medullary thyroid carcinoma
Autore:
Gimm, O; Sutter, T; Dralle, H;
Indirizzi:
Univ Halle Wittenberg, Klin Allgemeinchirurg, D-06097 Halle, Germany Univ Halle Wittenberg Halle Germany D-06097 rurg, D-06097 Halle, Germany
Titolo Testata:
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
fascicolo: 3, volume: 127, anno: 2001,
pagine: 156 - 165
SICI:
0171-5216(200103)127:3<156:DATOSA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE-ENDOCRINE-NEOPLASIA; PENTAGASTRIN STIMULATION TEST; RET-MUTATION-CONSORTIUM; CARCINOEMBRYONIC ANTIGEN; ROUTINE MEASUREMENT; PROGNOSTIC FACTORS; FOLLOW-UP; COMBINATION CHEMOTHERAPY; RADIOLABELED ANTIBODIES; MULTIVARIATE-ANALYSIS;
Keywords:
medullary thyroid carcinoma; MTC; diagnosis; therapy; sporadic; familial; hereditary; proto-oncogene; RET;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Dralle, H Univ Halle Wittenberg, Klin Allgemeinchirurg, Ernst Grube Str 40-42, D-06097 Halle, Germany Univ Halle Wittenberg Ernst Grube Str 40-42 Halle Germany D-06097
Citazione:
O. Gimm et al., "Diagnosis and therapy of sporadic and familial medullary thyroid carcinoma", J CANC RES, 127(3), 2001, pp. 156-165

Abstract

Medullary thyroid carcinoma (MTC) is a rare thyroid malignancy. About 75% are sporadic (sMTC) while the remaining 25% are hereditary (hMTC). The treatment of choice for both sMTC and hMTC is surgery. An adequate initial operation provides the best chance of cure. Hence, the diagnosis of MTC should be made preoperatively. In sMTC, ultrasound, ultrasound-guided fine-needle aspiration cytology and measurement of calcitonin levels (basal and after injection of calcitonin-stimulating reagents, e.g., pentagastrin) are sensitive diagnostic tools. In hMTC, identification of a germline mutation in theproto-oncogene RET is sufficient for making the diagnosis. Total thyroidectomy is recommended in all patients, sporadic and hereditary. In addition, lymphadenectomy of the cervicocentral and both cervicolateral compartments should be performed. The only indication to perform a less extensive operation may be given in young patients with hMTC. Sufficient treatment of MTC beyond local disease is still nonexistent. Future research should concentrate on this issue.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 23:29:07