Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Oxidative stress in normospermic men undergoing infertility evaluation
Autore:
Pasqualotto, FF; Sharma, RK; Kobayashi, H; Nelson, DR; Thomas, AJ; Agarwal, A;
Indirizzi:
Cleveland Clin Fdn, Dept Urol, Androl Res & Clin Labs,Urol Inst, Ctr Adv Res Human Reprod & Infertil, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 fertil, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Biostat & Epidemiol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 demiol, Cleveland, OH 44195 USA
Titolo Testata:
JOURNAL OF ANDROLOGY
fascicolo: 2, volume: 22, anno: 2001,
pagine: 316 - 322
SICI:
0196-3635(200103/04)22:2<316:OSINMU>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOTAL ANTIOXIDANT CAPACITY; OXYGEN SPECIES PRODUCTION; HUMAN-SPERMATOZOA; SEMINAL PLASMA; LIPID-PEROXIDATION; DNA FRAGMENTATION; SPERM MOTILITY; FERTILE; ASSOCIATION; GENERATION;
Keywords:
antioxidants; male infertility; reactive oxygen species; spermatozoa;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Agarwal, A Cleveland Clin Fdn, Dept Urol, Androl Res & Clin Labs,Urol Inst, Ctr Adv Res Human Reprod & Infertil, 9500 Euclid Ave,A19-1, Cleveland, OH44195 USA Cleveland Clin Fdn 9500 Euclid Ave,A19-1 Cleveland OH USA 44195
Citazione:
F.F. Pasqualotto et al., "Oxidative stress in normospermic men undergoing infertility evaluation", J ANDROLOGY, 22(2), 2001, pp. 316-322

Abstract

The purpose of this study was to determine whether normospermic infertile men have high seminal oxidative stress, using 3 measures of oxidative stress: reactive oxygen species (ROS), total antioxidant capacity (TAC), and a composite ROS-TAC score. Forty-three normospermic men without leukocytospermia and 19 healthy donors who came to our infertility clinic were included. Patients were categorized into 3 groups: group I, varicocele and no female factor (n = 16); group II, positive female factor (n = 16); and group III, idiopathic infertility (n = 11). In addition, 52 treated male factor patients and 19 donors were included as reference groups. We measured seminal ROS, TAG, and the ROS-TAC score in the patient groups and the controls. Normospermic infertile patients as a group had higher ROS levels (mean log [ROS 1] 1.76 +/- 0.13) compared with controls (1.39 +/- 0.16; P = .03). Patients in the idiopathic subgroup had significantly higher ROS levels (2.29 +/- 0.25; P = .004) than controls. Normospermic infertile patients as a group not only had reduced TAC levels (970.18 +/- 73.95 Trolox equivalents), but each subgroup also Had significantly lower TAC than controls (1650.93 +/- 95.87; P < .003). The ROS-TAC scores in all normospermic infertile patients as a group (35.7 +/- 1.8) as well as in each subgroup was significantly reduced compared with the ROS-TAC levers in the controls (50.0 +/- 2.1; P < .005). We conclude that oxidative stress is associated with mate factor infertility. The presence of oxidative stress in infertile normospermic men may explain previously unexplained cases of infertility otherwise attributed to female factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 01:16:19