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Titolo:
Epididymal growth and differentiation are altered in human cryptorchidism
Autore:
De Miguel, MP; Marino, JM; Gonzalez-Peramato, P; Nistal, M; Regadera, J;
Indirizzi:
Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA Hosp La Paz, Dept Pediat Surg, Madrid, Spain Hosp La Paz Madrid SpainHosp La Paz, Dept Pediat Surg, Madrid, Spain Autonomous Univ Madrid, Sch Med, Dept Morphol, E-28049 Madrid, Spain Autonomous Univ Madrid Madrid Spain E-28049 rphol, E-28049 Madrid, Spain Guadalajara Hosp, Dept Pathol, Guadalajara, Spain Guadalajara Hosp Guadalajara Spain osp, Dept Pathol, Guadalajara, Spain Hosp La Paz, Dept Pathol, Madrid, Spain Hosp La Paz Madrid SpainHosp La Paz, Dept Pathol, Madrid, Spain
Titolo Testata:
JOURNAL OF ANDROLOGY
fascicolo: 2, volume: 22, anno: 2001,
pagine: 212 - 225
SICI:
0196-3635(200103/04)22:2<212:EGADAA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MITOCHONDRIA-RICH CELLS; RAT CAUDA EPIDIDYMIDIS; TESTICULAR DESCENT; INTERMEDIATE FILAMENTS; SECRETORY PROTEINS; HORMONE RECEPTORS; ANDROGEN RECEPTOR; EPITHELIAL-CELLS; VAS-DEFERENS; HUMAN TESTIS;
Keywords:
efferent ducts; cytokeratins; immunohistochemistry; morphometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: De Miguel, MP Thomas Jefferson Univ, Kimmel Canc Ctr, 233 S 10th St,BLSB,Room 706, Philadelphia, PA 19107 USA Thomas Jefferson Univ 233 S 10th St,BLSB,Room 706 Philadelphia PA USA 19107
Citazione:
M.P. De Miguel et al., "Epididymal growth and differentiation are altered in human cryptorchidism", J ANDROLOGY, 22(2), 2001, pp. 212-225

Abstract

Despite the knowledge and histological classification of testicular lesions, epididymal lesions associated with cryptorchidism are not well defined and only macroscopic alterations have been reported. We have evaluated the alterations in the growth of both the epithelium and muscular wall of efferent ducts and epididymis in human patients with cryptorchidism from infancy to adulthood. In addition, by cytokeratin immunostaining we have also evaluated the stage of differentiation of each segment along the human postnatallife in these patients. A decrease is shown in the size of efferent and epididymal ducts in cryptorchid children compared with normal, age-matched controls. The height of the epithelium, muscular wall, and lumen of the cryptorchid epididymis were reduced at every age studied. This decrease in all regions was seen even in the testicular quiescent period (1 to 4 years of age). In addition, the cryptorchid epididymis grows more slowly during the transition to the pubertal period. The smaller size of the cryptorchid epididymis in pubertal and adult men compared with that of normal men is due primarily to underdevelopment of the muscular wall and a reduction in epithelial height. The pattern of growth of cryptorchid efferent ducts and ductus epididymides parallels that in normal men, except that development of the lumen and muscular layer in the cauda epididymis region are delayed. Epithelial differentiation. monitored by cytokeratin expression, is minimal in efferent ducts and throughout the epididymis of the cryptorchid male, and this is already seen in children. In conclusion, our immunohistochemical and morphometric results show a reduced development of the human cryptorchid epididymis that is already evident in childhood. They indicate that cryptorchidism is a primary congenital illness of the testis and spermatic ducts, with evident lesions from the first years of life, and suggest that surgical descent would probably not be able to completely reverse these alterations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:31:52