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Titolo:
No increased human herpesvirus 8 seroprevalence in patients with HIV-associated non-Hodgkin's lymphoma
Autore:
Gerard, L; Agbalika, F; Sheldon, J; Maillard, A; Schulz, TF; Oksenhendler, C;
Indirizzi:
Hop St Louis, Dept Immunol & Hematol, F-75010 Paris, France Hop St Louis Paris France F-75010 munol & Hematol, F-75010 Paris, France Hop St Louis, Virol Lab, Paris, France Hop St Louis Paris FranceHop St Louis, Virol Lab, Paris, France Dept Med Microbiol & Genitourinary Med, Liverpool, Merseyside, England Dept Med Microbiol & Genitourinary Med Liverpool Merseyside England land
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 2, volume: 26, anno: 2001,
pagine: 182 - 184
SICI:
1525-4135(20010201)26:2<182:NIHH8S>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED-IMMUNODEFICIENCY-SYNDROME; KAPOSIS-SARCOMA; DNA-SEQUENCES; HUMAN-HERPESVIRUS-8; ANTIBODIES; DISEASE; CELLS; RISK;
Keywords:
human herpesvirus 8; HIV; non-Hodgkins's lymphoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Gerard, L Hop St Louis, Serv Immunohematol, 1 Ave Claude Vellefaux, F-75010 Paris, France Hop St Louis 1 Ave Claude Vellefaux Paris France F-75010 France
Citazione:
L. Gerard et al., "No increased human herpesvirus 8 seroprevalence in patients with HIV-associated non-Hodgkin's lymphoma", J ACQ IMM D, 26(2), 2001, pp. 182-184

Abstract

Human herpesvirus 8 (HHV-8) is closely associated with Kaposi's sarcoma (KS), HIV-associated Castleman's disease, and primary effusion lymphoma. As ahigh frequency of non-Hodgkin's lymphoma (NHL) has been reported in patients with HIV-associated KS, we hypothesized that HHV-8 infection could be indirectly implicated in the pathogenesis of NHL. We assessed the prevalence of HHV-8 antibodies in 63 patients with NHL compared with 126 HIV-infected matched control patients without NHL. Serum samples from cases and controlswere assayed for antibodies to HHV-8 lyric and latent antigens using an indirect immunofluorescence assay. In patients with concordant serologic results, HHV-8 antibodies were detected in 41.5% of the NHL cases and 37% of the controls. This absence of a significant difference in HHV-8 seroprevalence between cases and controls (p =.73) does not support a possible role for HHV-8 infection in the development of NHL in HIV-infected patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:45:56