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Titolo:
Gender differences in virologic response to treatment in an HIV-positive population: A cohort study
Autore:
Moore, AL; Mocroft, A; Madge, S; Devereux, H; Wilson, D; Phillips, AN; Johnson, M;
Indirizzi:
Royal Free & Univ Coll Sch Med, Dept Primary Care & Populat Sci, London NW3 2PF, England Royal Free & Univ Coll Sch Med London England NW3 2PF n NW3 2PF, England Royal Free & Univ Coll Sch Med, Royal Free Ctr HIV Med, London NW3 2PF, England Royal Free & Univ Coll Sch Med London England NW3 2PF n NW3 2PF, England Royal Free & Univ Coll Sch Med, Dept Retrovirol, London NW3 2PF, England Royal Free & Univ Coll Sch Med London England NW3 2PF n NW3 2PF, England
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 2, volume: 26, anno: 2001,
pagine: 159 - 163
SICI:
1525-4135(20010201)26:2<159:GDIVRT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEX-DIFFERENCES; VIRAL LOAD; DRUG-USE; AIDS; PROGRESSION; SURVIVAL; DISEASE; MORTALITY;
Keywords:
gender; viral load; HAART;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Moore, AL Royal Free & Univ Coll Sch Med, Dept Primary Care & Populat Sci,London NW3 2PF, England Royal Free & Univ Coll Sch Med London England NW3 2PF England
Citazione:
A.L. Moore et al., "Gender differences in virologic response to treatment in an HIV-positive population: A cohort study", J ACQ IMM D, 26(2), 2001, pp. 159-163

Abstract

Objective: To establish whether a gender difference in virologic response to highly active antiretroviral treatment (HAART) exists. Methods: A cohort of HIV-positive individuals was examined. Outcomes: Achievement of viral load <500 copies/ml and "failure" (failure to suppress viral load <500 copies/ml after 24 weeks or two consecutive measurements above this level after having suppressed below it). Hazard ratios(HRs) comparing the rate in women to that in men were derived using the Cox model. Results: Of 366 male subjects, 79% were white: and 82% were homosexual. Sixty-three percent of the 91 female subjects were African and 87% were heterosexual. The median follow-up after HAART was 94 weeks. The baseline CD4 count was higher in men (228 x 10(6) per liter) than in women (171 x 10(6) per liter) (p =.01), but the viral load was similar (p = .88). The median time to <500 copies/ml was 16 weeks. Women achieved a viral load of <500 copies/ml at a faster rate than men, with an adjusted HR of 1.46 (95% confidenceinterval [CI]: 0.99-2.16; p = .06). Some 261 patients failed treatment (58% of men and 53% of women) with an HR of 0.78 (95% CI: 0.51-1.21; P = .27). Conclusions: Women may achieve virologic suppression at a faster rate thanmen and have a more durable response. Further research should examine these responses in conjunction with clinical outcomes, because gender differences in virologic response may ultimately be of little relevance if clinical outcomes are similar.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 12:23:40