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Titolo:
In vitro effects of recombinant TNF-alpha binding protein (rTBP-1) on hematopoiesis of HIV-infected patients
Autore:
Gradstein, S; Hahn, T; Barak, Y; Malach, L; Revel, M; Bentwich, Z; Handzel, ZT;
Indirizzi:
Kaplan Med Ctr, Pediat Res Inst, IL-76100 Rehovot, Israel Kaplan Med Ctr Rehovot Israel IL-76100 es Inst, IL-76100 Rehovot, Israel Interpharm Labs, Ness Ziona, Israel Interpharm Labs Ness Ziona IsraelInterpharm Labs, Ness Ziona, Israel
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 2, volume: 26, anno: 2001,
pagine: 111 - 117
SICI:
1525-4135(20010201)26:2<111:IVEORT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; HUMAN-IMMUNODEFICIENCY-VIRUS; COLONY-STIMULATING FACTOR; STEM-CELL FACTOR; IN-VITRO; PROGENITOR CELLS; FACTOR (TNF)-ALPHA; TYPE-1 INFECTION; INTERFERON-GAMMA; FACTOR RECEPTORS;
Keywords:
AIDS; TNF-alpha; soluble TNF-alpha receptor; hematopoiesis; TNF-binding protein 1; GM-CFC; BFU-E;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Handzel, ZT Kaplan Med Ctr, Pediat Res Inst, IL-76100 Rehovot, Israel Kaplan Med Ctr Rehovot Israel IL-76100 76100 Rehovot, Israel
Citazione:
S. Gradstein et al., "In vitro effects of recombinant TNF-alpha binding protein (rTBP-1) on hematopoiesis of HIV-infected patients", J ACQ IMM D, 26(2), 2001, pp. 111-117

Abstract

Tumor necrosis factor-alpha (TNF-alpha) is believed to contribute to the hematopoietic failure often observed in patients with AIDS. Soluble TNF receptors (sTNFR) compete for TNF-alpha with cell surface receptors and thus may block its activity. The effect of the p55 sTNFR (recombinant TNF-binding protein-1 [rTBP-1]) on the clonogenic growth of hematopoietic progenitor cells from 27 HIV-infected patients was evaluated in comparison with 11 normal study subjects. Peripheral blood-derived, myelopoietic (i.e., granulomonocytic colony-forming cells [GM-CFC]) and erythropoietic (i.e, burst-formingunit, erythroid [BFU-E]) colonies were grown in 10-day semisolid cultures with increasing concentrations of rTBP-1. Significantly, dose-dependent increases occurred in GM-CFC from 17 of 21 AIDS patients and 12 of 21 in BFU-Eat rTBP-1 concentrations of 1 mu /ml to 25 mu /ml. In contrast, rTBP-1 failed to induce any appreciably increased colony formation in normal cell cultures. In 6 patients treated with highly active antiretroviral treatment (HAART), TBP-1 alone did not demonstrate the in vitro hematopoiesis-enhancingeffect. This study may provide an initial step in development of therapeutic use of TBP as a TNF-alpha antagonist in HIV-infected patients who do notbenefit sufficiently from antiretroviral treatment, and in other conditions in which increased levels of TNF-alpha may contribute to hematopoietic deficiencies.

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Documento generato il 23/01/20 alle ore 12:26:57