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Titolo:
Acute optic neuritis in children: clinical features and treatment. A studyof 20 cases (28 eyes)
Autore:
Roussat, B; Gohier, P; Doummar, D; Iba-Zizen, MT; Barbat, V; Jarry, D; Cabanis, EA; Hamard, H; Nordmann, JP;
Indirizzi:
Ctr Hosp Natl Ophtalmol Quinze Vingts, Serv Ophtalmol, F-75012 Paris, France Ctr Hosp Natl Ophtalmol Quinze Vingts Paris France F-75012 Paris, France
Titolo Testata:
JOURNAL FRANCAIS D OPHTALMOLOGIE
fascicolo: 1, volume: 24, anno: 2001,
pagine: 36 - 44
SICI:
0181-5512(200101)24:1<36:AONICC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
FRE
Soggetto:
BARR-VIRUS-INFECTION; HEPATITIS-B VACCINE; MULTIPLE-SCLEROSIS; NEUROMYELITIS-OPTICA; CHILDHOOD; DISEASE;
Keywords:
acute optic neuritis; optic nerve oedema; psychological loss of visual acuity; multiple sclerosis; vaccination against hepatitis B (complications); acute disseminated encephalomyelitis; Schilder's disease; intravenous corticotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Roussat, B Ctr Hosp Natl Ophtalmol Quinze Vingts, Serv Ophtalmol, 28 Rue Charenton, F-75012 Paris, France Ctr Hosp Natl Ophtalmol Quinze Vingts 28 Rue Charenton Paris France F-75012
Citazione:
B. Roussat et al., "Acute optic neuritis in children: clinical features and treatment. A studyof 20 cases (28 eyes)", J FR OPHTAL, 24(1), 2001, pp. 36-44

Abstract

Purpose: Analyzing a personal series of children with acute optic neuritis(AON), we studied: 1) etiology, 2) the risk of progression to multiple sclerosis, 3) the therapeutical management of the onset. Material and methods: A retrospective study of 28 eyes in 20 patients (mean age: 10;7 years), examined between 1982 and 1997, with a follow-up ranging from 6 months to 15 years (mean: 5;5 years). We recorded etiologic factors, clinical features (ocular and extra ocular), biological results, and neuroimaging findings. Results: Initial involvement was uni- or bilateral with poor visual acuity(under 20/200 in 22 eyes of 28). Intracerebral inflammation was present in9 of 13 cases where MRI was performed. We found a cause in only 7 cases (5viral diseases and 2 recent vaccinations against hepatitis B). Visual recovery was good lover 20/25 in 20 eyes of 28) whatever the treatment, but AONrecurred in 5 children. Four children later developed multiple sclerosis. Conclusions: The cause of AON is rarely found. After eliminating an infection, we retained viral disease, complication of a recent vaccination against hepatitis B, and neurological diseases. MRI was the imaging study of choice. Development of multiple sclerosis occurred in 4 cases of 20, the same frequency as in the literature. The risk of later development of multiple sclerosis was 20%. Progression of AON was often excellent. Nevertheless, corticotherapy was added, in form of intravenous boluses followed by decreasingoral therapy for one month.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:13:47