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Titolo:
Early onset methotrexate-induced pancytopenia and response to G-CSF: A report of two cases
Autore:
Yoon, KH; Ng, SC;
Indirizzi:
Natl Univ Singapore Hosp, Dept Med, Singapore 0511, Singapore Natl Univ Singapore Hosp Singapore Singapore 0511 gapore 0511, Singapore Alexandra Hosp, Dept Med, Singapore, Singapore Alexandra Hosp Singapore Singapore Hosp, Dept Med, Singapore, Singapore
Titolo Testata:
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
fascicolo: 1, volume: 7, anno: 2001,
pagine: 17 - 20
SICI:
1076-1608(200102)7:1<17:EOMPAR>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DOSE METHOTREXATE; RHEUMATOID-ARTHRITIS; THERAPY; NEUTROPENIA; SECONDARY; TOXICITY; FAILURE; BENEFIT;
Keywords:
methotrexate; early onset; pancytopenia; rheumatoid arthritis; granulocyte colony-stimulating factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Yoon, KH 5 Lower Kent Ridge Rd, Singapore 119074, Singapore 5 Lower Kent Ridge Rd Singapore Singapore 119074 074, Singapore
Citazione:
K.H. Yoon e S.C. Ng, "Early onset methotrexate-induced pancytopenia and response to G-CSF: A report of two cases", JCR-J CLIN, 7(1), 2001, pp. 17-20

Abstract

Methotrexate (MTX) is one of the most widely used antirheumatic drugs for the treatment of rheumatoid arthritis. Whereas the hepatotoxicity of methotrexate is well recognized, the hematologic toxicity, namely, pancytopenia, is still a concern and is potentially fatal. We report two cases of early-onset methotrexate-induced pancytopenia that were successfully treated with granulocyte colony-stimulating factor (G-CSF). The pancytopenia improved with 3 days of administration. A review of the literature revealed at least 146 reported cases of MTX-induced pancytopenia. Significant risk factors formyelotoxicity included renal impairment, infection, and hypoalbuminemia. Successful management includes prompt discontinuation of MTX, intravenous folinic acid, high-dose steroids and, as in our case, G-CSF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:19:31