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Titolo:
Short term hypercholesterolemia alters N-G-nitro-L-arginine- and indomethacin-resistant endothelium-dependent relaxation by acetylcholine in rabbit renal artery
Autore:
Honda, H; Moroe, H; Fujii, H; Arai, K; Notoya, Y; Kogo, H;
Indirizzi:
Tokyo Univ Pharm & Life Sci, Dept Pharmacol, Hachioji, Tokyo 1920392, Japan Tokyo Univ Pharm & Life Sci Hachioji Tokyo Japan 1920392 o 1920392, Japan Tokyo Med Univ, Dept Internal Med, Shinjuku Ku, Tokyo 1600023, Japan TokyoMed Univ Tokyo Japan 1600023 ed, Shinjuku Ku, Tokyo 1600023, Japan
Titolo Testata:
JAPANESE JOURNAL OF PHARMACOLOGY
fascicolo: 2, volume: 85, anno: 2001,
pagine: 203 - 206
SICI:
0021-5198(200102)85:2<203:STHANA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPERPOLARIZING FACTOR; VASCULAR ENDOTHELIUM; OXIDE; MECHANISMS; AORTA;
Keywords:
hypercholesterolemia; renal artery; endothelium-derived hyperpolarizing factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Honda, H Tokyo Univ Pharm & Life Sci, Dept Pharmacol, 1432-1 Horinouchi, Hachioji, Tokyo 1920392, Japan Tokyo Univ Pharm & Life Sci 1432-1 HorinouchiHachioji Tokyo Japan 1920392
Citazione:
H. Honda et al., "Short term hypercholesterolemia alters N-G-nitro-L-arginine- and indomethacin-resistant endothelium-dependent relaxation by acetylcholine in rabbit renal artery", JPN J PHARM, 85(2), 2001, pp. 203-206

Abstract

The tension of isolated rings was measured isometrically to compare the N-G-nitro-L-arginine- and indomethacin-resistant relaxation by acetylcholine (ACh) in the renal artery from normal rabbits and short term hypercholesterolemia rabbits (0.5% cholesterol chow for 5 weeks). ACh-induced relaxation in the renal artery precontracted with phenylephrine was not influenced by cholesterol-enriched chow. However, in comparison with artery from normal rabbits, the N-G-nitro-L-arginine- and indomethacin-resistant endothelium-dependent relaxation by ACh was significantly enhanced by the chow. The resistant part of ACh-induced relaxation was significantly inhibited when the artery was treated with tetraethylammonium or SKF 525a. Results suggest that short term hypercholesterolemia modulates endothelium-derived hyperpolarizing factor-mediated relaxation in rabbit renal artery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 00:07:03