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Titolo:
Biological characteristics of carcinomatosa pleuritis in orthotopic model systems using immune-defficient rats
Autore:
Ohta, Y; Kimura, K; Tamura, M; Oda, M; Tanaka, M; Sasaki, T; Watanabe, G;
Indirizzi:
Kanazawa Univ, Sch Med, Dept Surg 1, Kanazawa, Ishikawa 9208641, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208641 wa, Ishikawa 9208641, Japan Kanazawa Univ, Canc Res Inst, Dept Expt Therapeut, Kanazawa, Ishikawa 9208641, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208641 wa, Ishikawa 9208641, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 3, volume: 18, anno: 2001,
pagine: 499 - 505
SICI:
1019-6439(200103)18:3<499:BCOCPI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR-PERMEABILITY FACTOR; AUTOCRINE MOTILITY FACTOR; ENDOTHELIAL GROWTH-FACTOR; PRIMARY LUNG-CANCER; PLEURAL DISSEMINATION; MESOTHELIOMA; EXPRESSION; RECEPTOR;
Keywords:
VEGF; lung cancer; pleural dissemination; carcinomatosa pleuritis; model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Ohta, Y Kanazawa Univ, Sch Med, Dept Surg 1, Kanazawa, Ishikawa 9208641, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208641 kawa 9208641, Japan
Citazione:
Y. Ohta et al., "Biological characteristics of carcinomatosa pleuritis in orthotopic model systems using immune-defficient rats", INT J ONCOL, 18(3), 2001, pp. 499-505

Abstract

We assessed the association of vascular endothelial growth factor (VEGF) on the formation of carcinomatosa pleuritis in orthotopic model systems. Immune-deficient rats were inoculated with PC-14 cells into i) a subpleural space of the parietal pleura after pneumonectomy or ii) into the thoracic cavity directly. The rats bearing tumor cells were randomly separated into twogroups: non-treatment and treatment with anti-VEGF neutralizing antibody groups. At the time of the autopsy, all rats developed gross pleural dissemination with/without malignant effusions. In the first model, despite no significant difference in the mean volume of the subpleural tumors between thegroups, the degree of dissemination was suppressed in the treatment group with less tumor vasculature and with reduced expression of autocrine motility factor receptor (AMFR) in tumor cells. In the second model, although theinhibitory effect on dissemination was not clear, the formation of pleuraleffusion was inhibited in the treatment group. In addition to the ability of vascular permeability, the results demonstrated here showed the possibleassociation of VEGF with the development of pleural dissemination/metastasis in the context of blood/lymphatic routes and cancer cell motility affected by AMFR.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:10:21