Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Plasma leptin concentrations and four-year weight gain among US men
Autore:
Chu, NF; Spiegelman, D; Yu, J; Rifai, N; Hotamisligil, GS; Rimm, EB;
Indirizzi:
Natl Def Med Ctr, Tri Serv Gen Hosp, Dept Community Med, Taipei, Taiwan Natl Def Med Ctr Taipei Taiwan Hosp, Dept Community Med, Taipei, Taiwan Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 th, Dept Epidemiol, Boston, MA 02115 USA Natl Def Med Ctr, Tri Serv Gen Hosp, Dept Publ Hlth, Taipei, Taiwan Natl Def Med Ctr Taipei Taiwan Gen Hosp, Dept Publ Hlth, Taipei, Taiwan Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Hlth, Dept Biostat, Boston, MA 02115 USA Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA Harvard UnivBoston MA USA 02115 bl Hlth, Dept Nutr, Boston, MA 02115 USA Childrens Hosp, Dept Lab Med, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 sp, Dept Lab Med, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 h Med, Dept Pathol, Boston, MA 02115 USA Harvard Univ, Sch Publ Hlth, Div Biol Sci, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Hlth, Div Biol Sci, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Med, Channing Lab, Boston, MA USA Harvard Univ Boston MA USA h Med, Dept Med, Channing Lab, Boston, MA USA Brigham & Womens Hosp, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 mens Hosp, Boston, MA 02115 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF OBESITY
fascicolo: 3, volume: 25, anno: 2001,
pagine: 346 - 353
SICI:
0307-0565(200103)25:3<346:PLCAFW>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALE HEALTH-PROFESSIONALS; BODY-MASS INDEX; OBESE OB GENE; SERUM LEPTIN; MEXICAN-AMERICANS; FAT DISTRIBUTION; PIMA-INDIANS; HUMANS; QUESTIONNAIRE; RESISTANCE;
Keywords:
leptin; weight gain; men;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Chu, NF Natl Def Med Ctr, Tri Serv Gen Hosp, Dept Community Med, POB 90048-509, Taipei, Taiwan Natl Def Med Ctr POB 90048-509 Taipei Taiwan 509, Taipei, Taiwan
Citazione:
N.F. Chu et al., "Plasma leptin concentrations and four-year weight gain among US men", INT J OBES, 25(3), 2001, pp. 346-353

Abstract

OBJECTIVE: Leptin, a primarily adipose tissue-derived protein product of the obesity (ob) gene, is an important regulator of energy metabolism. The strong association between body fat mass and elevated circulating leptin levels in humans suggests that leptin resistance, rather than leptin production, may contribute to the development of obesity and associated disorders. The purpose of this study is to evaluate the relationship between circulating plasma leptin levels and regulation of body weight over time among US men. DESIGN: Four-year prospective study. SUBJECTS: A total of 247 men from the Health Professionals Follow-up Study, who at baseline (1994), were 47-64 y of age, were free of cardiovascular diseases, diabetes mellitus and malignant neoplasmas, and completed a detailed lifestyle questionnaire. In addition, all participants completed a follow-up questionnaire in 1998. MEASUREMENTS: Baseline plasma leptin levels and 4-y weight change. RESULTS: At the start of follow-up, men in the highest quintile for plasmaleptin (mean = 12.1 ng/ml) weighed more, were less physically active, and had higher circulating insulin levels than men in the lowest quintile (mean= 2.7 ng/ml). After adjustments for baseline age, weight, height, smoking status, alcohol intake, and physical activity, each 10 ng/ml increase in plasma leptin concentration was associated with a 1.68 kg (95% CI 0.14-3.18 kg) weight gain over the 4-y follow-up period. The observed association between leptin level and weight gain was limited to men with a baseline body mass index (BMI) of greater than or equal to 25 kg/m(2), in whom a 10ng/ml higher baseline leptin was associated with a 2.45 kg (95% CI 0.73-4.18-kg) weight gain. Further adjustments for baseline total energy intake, plasma insulin and soluble tumor necrosis factor receptors levels did not appreciablyalter these results. Plasma insulin level was not independently associatedwith subsequent weight gain. CONCLUSION: These results suggest that elevated plasma leptin concentrations among overweight men may be a marker of leptin resistance and subsequentweight gain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 05:59:56