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Titolo:
Apoptosis related gene products in differentiated and tumorigenic rat Leydig cells and following regression induced by the cytotoxin ethane dimethanesulphonate
Autore:
Woolveridge, I; Taylor, MF; Rommerts, FFG; Morris, ID;
Indirizzi:
Univ Manchester, Sch Biol Sci, Div Physiol Pharmacol & Toxicol, ManchesterM13 9PT, Lancs, England Univ Manchester Manchester Lancs England M13 9PT rM13 9PT, Lancs, England Erasmus Univ, Dept Endocrinol & Reprod, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 DR DR Rotterdam, Netherlands
Titolo Testata:
INTERNATIONAL JOURNAL OF ANDROLOGY
fascicolo: 1, volume: 24, anno: 2001,
pagine: 56 - 64
SICI:
0105-6263(200102)24:1<56:ARGPID>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA STRAND BREAKS; SULFATED GLYCOPROTEIN-2; TEMPORAL CHANGES; DIMETHANESULFONATE; CLUSTERIN; TESTIS; DEATH; MECHANISMS; BCL-2; HYPERPLASIA;
Keywords:
apoptosis; Bax; Bcl-2; clusterin; EDS; Leydig; programmed cell death; tumour;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Morris, ID Univ Manchester, Sch Biol Sci, Div Physiol Pharmacol & Toxicol,G38 Stopford Bldg,Oxford Rd, Manchester M13 9PT, Lancs, England Univ Manchester G38 Stopford Bldg,Oxford Rd Manchester Lancs England M13 9PT
Citazione:
I. Woolveridge et al., "Apoptosis related gene products in differentiated and tumorigenic rat Leydig cells and following regression induced by the cytotoxin ethane dimethanesulphonate", INT J ANDR, 24(1), 2001, pp. 56-64

Abstract

Androgen secreting Leydig cells in the adult are differentiated with a very low turnover, however, Leydig cell tumours can arise spontaneously or after treatment with toxins. This study in the rat investigated whether changes in components of programmed cell death could be involved. In contrast to their absence in differentiated Leydig cells, antiapoptotic Bcl-2 and proapoptotic Bax were expressed in tumours. Bak and Bcl-xl were found in both tumour and normal Levdig cells, Apoptosis was induced in subcutaneous implants of Leydig cell tumour by ethane dimethanesulphonate (EDS) which is known to kill differentiated Leydig cells. The marked regression of the tumour following EDS treatment was transient and re-growth occurred between 6 and 14days later. Tumour regression and growth was associated with a similar weight pattern in the seminal vesicles caused by changes in serum testosterone. During tumour regression, clusterin and Bax proteins were elevated but Bak, Bcl-xl and Bcl-2 were unchanged, Fas-R, Fas-L and Bax were upregulated after tumour regression had taken place. These data show that Leydig cell tumours possess many of the apoptosis related gene products and carl die by apoptosis, however, regulation is clearly different in differentiated and mitotic Leydig cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 00:42:33