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Titolo:
Role of mast cells in intestinal mucosal function: studies in models of hypersensitivity and stress
Autore:
Yu, LCH; Perdue, MH;
Indirizzi:
McMaster Univ, Intestinal Dis Res Program, Dept Pathol & Mol Med, Hamilton, ON L8N 3Z5, Canada McMaster Univ Hamilton ON Canada L8N 3Z5 ed, Hamilton, ON L8N 3Z5, Canada
Titolo Testata:
IMMUNOLOGICAL REVIEWS
, volume: 179, anno: 2001,
pagine: 61 - 73
SICI:
0105-2896(200102)179:<61:ROMCII>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; ION-TRANSPORT ABNORMALITIES; PLATELET-ACTIVATING-FACTOR; PIG DISTAL COLON; SUBSTANCE-P; ELECTROLYTE TRANSPORT; CHLORIDE SECRETION; RAT JEJUNUM; IN-VITRO; MONONUCLEAR-CELLS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
90
Recensione:
Indirizzi per estratti:
Indirizzo: Perdue, MH McMaster Univ, Intestinal Dis Res Program, Dept Pathol & Mol Med, HSC-3N5C,1200 Main St W, Hamilton, ON L8N 3Z5, Canada McMaster Univ HSC-3N5C,1200 Main St W Hamilton ON Canada L8N 3Z5
Citazione:
L.C.H. Yu e M.H. Perdue, "Role of mast cells in intestinal mucosal function: studies in models of hypersensitivity and stress", IMMUNOL REV, 179, 2001, pp. 61-73

Abstract

A single layer of epithelial cells lines the gastrointestinal tract, forming a critical barrier between die luminal contents. which includes antigensand other noxious substances, and the body proper. Ir has become clear in recent years that the role of mast cells in the gastrointestinal mucosa is not only to react to antigens, bur also to actively regulate the barrier and transport properties of the intestinal epithelium. Mucosal mast cells respond to both IgE/antigen-dependent and non-IgE-dependent stimulation, releasing bioactive mediators into adjacent tissues where they induce physiological responses. Studies in models of hypersensitivity and stress have provided evidence that changes in mucosal function are due to either direct action of mast cell mediators on epithelial receptors and/or indirect action vianerves/neurotransmitters.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:43:50