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Titolo:
Novel approaches to the treatment of depression by modulating the hypothalamic-pituitary-adrenal axis
Autore:
Dinan, TG;
Indirizzi:
Royal Coll Surg Ireland, Dept Psychiat, Dublin 2, Ireland Royal Coll Surg Ireland Dublin Ireland 2 ept Psychiat, Dublin 2, Ireland
Titolo Testata:
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
fascicolo: 1, volume: 16, anno: 2001,
pagine: 89 - 93
SICI:
0885-6222(200101)16:1<89:NATTTO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; MELANCHOLIC DEPRESSION; CEREBROSPINAL-FLUID; MAJOR DEPRESSION; BETA-ENDORPHIN; HORMONE; DISORDERS;
Keywords:
depression; cortisol; hypothalamic-pituitary-adrenal axis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Dinan, TG Royal Coll Surg Ireland, Dept Psychiat, Dublin 2, Ireland Royal Coll Surg Ireland Dublin Ireland 2 at, Dublin 2, Ireland
Citazione:
T.G. Dinan, "Novel approaches to the treatment of depression by modulating the hypothalamic-pituitary-adrenal axis", HUM PSYCHOP, 16(1), 2001, pp. 89-93

Abstract

Many patients with major depression show evidence of over-activation of the hypothalamic-pituitary-adrenal axis (HPA), as evidenced by hypercortisolism and adrenal hyperplasia. Such over-activity is associated with increasedcorticotropin releasing factor (CRF) reactivity in the CSF and blunted release of ACTH in response to CRF infusion. Recent evidence suggests a switchfrom CRF to AVP regulation of the axis during depression, with depressed patients showing enhanced response to ddAVP infusion. The HPA provides multiple potential sites for antidepressant development. The use of glucocorticoid antagonists, cortisol synthesis inhibitors, CRF and AVP antagonists havebeen suggested, Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:24:19