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Titolo:
Are CRF receptor antagonists potential antidepressants?
Autore:
OBrien, D; Skelton, KH; Owens, MJJ; Nemeroff, CB;
Indirizzi:
Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Lab Neuropsychopharmacol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 uropsychopharmacol, Atlanta, GA 30322 USA
Titolo Testata:
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
fascicolo: 1, volume: 16, anno: 2001,
pagine: 81 - 87
SICI:
0885-6222(200101)16:1<81:ACRAPA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; FACTOR-LIKE IMMUNOREACTIVITY; CENTRAL-NERVOUS-SYSTEM; DEPRESSED-PATIENTS; NONPEPTIDE ANTAGONIST; BEHAVIORAL-RESPONSES; ENDOCRINE RESPONSES; CEREBROSPINAL-FLUID; BETA-ENDORPHIN; RAT-BRAIN;
Keywords:
CRF; CRF antagonists; depression; anxiety; stress; antidepressants;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Nemeroff, CB Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Lab Neuropsychopharmacol, 1639 Pierce Dr,Suite 4000, Atlanta, GA 30322 USA Emory Univ 1639 Pierce Dr,Suite 4000 Atlanta GA USA 30322 USA
Citazione:
D. O'Brien et al., "Are CRF receptor antagonists potential antidepressants?", HUM PSYCHOP, 16(1), 2001, pp. 81-87

Abstract

Corticotropin-releasing factor (CRF) is the major regulator of the hypothalamic-pituitary-adrenal (HPA) axis, and plays a key role in coordinating the endocrine, as well as autonomic and behavioral responses of an organism to stress. Direct CNS administration of CRF to laboratory animals produces an aggregate of effects that mimic the mammalian stress response. Impeding CRF function with CNS administration of a peptidergic CRF antagonist can block these manifestations of the stress response whether produced by exogenous CRF or occurring naturally in response to a stressor. A role for hypersecretion of CRF in the pathophysiology of depression is suggested by the finding that CNS administration of CRF mirrors many of the signs and symptoms utilized as diagnostic criteria for major depression. in addition, a large body of clinical evidence points to excess hypothalamic secretion of CRF andan accompanying HPA axis hyperactivity in patients with major depression. The recent development of selective, small molecule CRF1 receptor antagonists, which block the effects of CRF both in vitro and in vivo, suggest that these compounds may be effective in the treatment of affective and anxiety disorders. Early evidence indicates that these agents possess anxiolytic and antidepressant activity in animal behavioral models. Copyright (C) 2001 John Wiley & Sons, Ltd.

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Documento generato il 22/01/20 alle ore 06:41:02