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Titolo:
Neurotrophins: Possible role in affective disorders
Autore:
Sandler, M;
Indirizzi:
Queen Charlottes & Chelsea Hosp, London W6 0XG, England Queen Charlottes &Chelsea Hosp London England W6 0XG on W6 0XG, England
Titolo Testata:
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
fascicolo: 1, volume: 16, anno: 2001,
pagine: 61 - 64
SICI:
0885-6222(200101)16:1<61:NPRIAD>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; TRKB MESSENGER-RNA; MAJOR DEPRESSION; RAT HIPPOCAMPUS; BRAIN; EXPRESSION; CREB; INCREASES; NEURONS; BINDING;
Keywords:
monoamines; noradrenaline; 5-hydroxytryptamine (5-HT); neurotrophins; nerve growth factor (NGF); brain-derived neurotrophic factor (BDNF);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Sandler, M Queen Charlottes & Chelsea Hosp, Goldhawk Rd, London W6 0XG, England Queen Charlottes & Chelsea Hosp Goldhawk Rd London England W6 0XG
Citazione:
M. Sandler, "Neurotrophins: Possible role in affective disorders", HUM PSYCHOP, 16(1), 2001, pp. 61-64

Abstract

Various monoamine hypotheses of affective disorders have been unable to provide a complete explanation for the observed clinical findings. Recently Duman ct al. (1997) have produced a molecular and cellular theory of depression which seems to be a worthy successor to these hypotheses. Whereas the earlier theories were unable to explain the time lag between antidepressant drug administration and lightening of affect, Duman's group pinpoints intracellular mechanisms, in the right time frame, which decrease or increase the generation of neurotrophic factors necessary for the survival of certain neurons, particularly in the hippocampus. This new concept may lead to novel therapeutic approaches. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:35:52