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Titolo:
Retrograde amnesia after hippocampal damage: Recent vs. remote memories intwo tasks
Autore:
Sutherland, RJ; Weisend, MP; Mumby, D; Astur, RS; Hanlon, FM; Koerner, A; Thomas, MJ; Wu, Y; Moses, SN; Cole, C; Hamilton, DA; Hoesing, JM;
Indirizzi:
Univ New Mexico, Dept Psychol, Albuquerque, NM 87131 USA Univ New Mexico Albuquerque NM USA 87131 ychol, Albuquerque, NM 87131 USA Univ New Mexico, Dept Neurosci, Albuquerque, NM 87131 USA Univ New MexicoAlbuquerque NM USA 87131 rosci, Albuquerque, NM 87131 USA
Titolo Testata:
HIPPOCAMPUS
fascicolo: 1, volume: 11, anno: 2001,
pagine: 27 - 42
SICI:
1050-9631(2001)11:1<27:RAAHDR>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONFIGURAL ASSOCIATION THEORY; TEMPORAL GRADIENT; CONTEXTUAL FEAR; ELECTROCONVULSIVE-THERAPY; ALZHEIMERS-DISEASE; DORSAL HIPPOCAMPAL; IBOTENATE LESIONS; RATS; AMYGDALA; TERM;
Keywords:
consolidation; retrograde amnesia; spatial retrieval; relational configural visual discrimination; place learning;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
118
Recensione:
Indirizzi per estratti:
Indirizzo: Sutherland, RJ Univ New Mexico, Dept Psychol, Logan Hall, Albuquerque, NM 87131 USA Univ New Mexico Logan Hall Albuquerque NM USA 87131 131 USA
Citazione:
R.J. Sutherland et al., "Retrograde amnesia after hippocampal damage: Recent vs. remote memories intwo tasks", HIPPOCAMPUS, 11(1), 2001, pp. 27-42

Abstract

We review evidence from experiments conducted in our laboratory on retrograde amnesia in rats with damage to the hippocampal formation. In a new experiment reported here, we show that N-methyl-D-aspartate (NMDA)-induced hippocampal damage produced retrograde amnesia for both hidden platform and two-choice visible platform discriminations in the Morris water task. For bothproblems there was a significant trend for longer training-surgery intervals to be associated with worse retention performance. Little support is offered by our work for the concept that there is a process involving hippocampal-dependent consolidation of memories in extrahippocampal permanent storage sites. Longterm memory consolidation may take place within the hippocampus. The hippocampus may be involved permanently in storage and/or retrievalof a variety of relational and nonrelational memories if it was intact at the time of learning, even involving information which is definitely not affected in anterograde amnesia after hippocampal damage. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:27:44