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Titolo:
Consolidation and the medial temporal lobe revisited: Methodological considerations
Autore:
Murray, EA; Bussey, TJ;
Indirizzi:
NIMH, Neuropsychol Lab, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892NIMH, Neuropsychol Lab, Bethesda, MD 20892 USA
Titolo Testata:
HIPPOCAMPUS
fascicolo: 1, volume: 11, anno: 2001,
pagine: 1 - 7
SICI:
1050-9631(2001)11:1<1:CATMTL>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRADED RETROGRADE-AMNESIA; ENTORHINAL CORTEX; RHESUS-MONKEYS; SPATIAL DISCRIMINATION; ANTEROGRADE AMNESIA; FORNIX TRANSECTION; MEMORY IMPAIRMENT; PARIETAL CORTEX; RHINAL CORTEX; LESIONS;
Keywords:
hippocampus; perirhinal cortex; nonhuman primates; retrograde memory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Murray, EA NIMH, Neuropsychol Lab, Bldg 49,Room 1B80, Bethesda, MD 20892 USA NIMH Bldg 49,Room 1B80 Bethesda MD USA 20892 esda, MD 20892 USA
Citazione:
E.A. Murray e T.J. Bussey, "Consolidation and the medial temporal lobe revisited: Methodological considerations", HIPPOCAMPUS, 11(1), 2001, pp. 1-7

Abstract

It is widely believed that new memories are stored in the medial temporal lobe structures in the short term, but then are reorganized over time as the neocortex gradually comes to support stable long-term storage. On this view, the medial temporal lobe structures play a time-limited role in information storage. This putative process of reorganization, known as consolidation, is supported by some clinical findings in humans and by some data from nonhuman animals. Here we review prospective studies of retrograde memory in nonhuman animals, with particular emphasis on experimental design. In considering the evidence for a time-limited role for the medial temporal lobe in information storage, we note that there are alternative interpretations for at least some of the findings typically cited in support of the consolidation process. In addition, we suggest that some studies arguing against the consolidation view should probably be given move weight than they have so far received. Finally, we observe that different structures in the medialtemporal lobe are unlikely to operate together as a single functional unitmediating a single consolidation process. Although evidence for a time-limited role for medial temporal lobe structures in memory is at present equivocal, future studies that consider some of the alternative accounts we and others have identified will provide a clearer picture of the mechanisms underlying information storage and retrieval in the brain. Published 2001 Wiley-Liss, Inc.dagger

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:55:56