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Titolo:
Identification and expression of a novel gene in odour-taste associative learning in the terrestrial slug
Autore:
Nakaya, T; Kawahara, S; Watanabe, S; Lee, DS; Suzuki, T; Kirino, Y;
Indirizzi:
Univ Tokyo, Sch Pharmaceut Sci, Lab Neurobiophys, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 obiophys, Bunkyo Ku, Tokyo 1130033, Japan
Titolo Testata:
GENES TO CELLS
fascicolo: 1, volume: 6, anno: 2001,
pagine: 43 - 56
SICI:
1356-9597(200101)6:1<43:IAEOAN>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; OLFACTORY INTERNEURONS; LIMAX-MARGINATUS; APLYSIA LEADS; PROTEIN; ADHESION; MEMORY; RESPONSES; BRAIN; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, T Univ Tokyo, Sch Pharmaceut Sci, Lab Neurobiophys, Bunkyo Ku, Hongo 7-3-1, Tokyo 1130033, Japan Univ Tokyo Hongo 7-3-1 Tokyo Japan 1130033 Tokyo 1130033, Japan
Citazione:
T. Nakaya et al., "Identification and expression of a novel gene in odour-taste associative learning in the terrestrial slug", GENES CELLS, 6(1), 2001, pp. 43-56

Abstract

Background: Odour-taste associative learning in the terrestrial slug offers a useful model for long-term memory formation and retention. The genes which are expressed over 2 h after a learning event are thought to include those related to memory formation and/or consolidation. It is very important to examine what kinds of genes are expressed following associative learning. Results: We identified a novel slug gene, the expression of which was regulated by associative learning and mostly restricted to the procerebrum (PC), a place that olfactory information is believed to be processed in slug. This gene encodes a 121 amino acid, 18 kDa secretory protein which we term LAPS18. Expression of the LAPS18 gene was induced in somata and the protein spread to neurites in the PC of slugs subjected to paired conditioning. Recombinant LAPS18 promoted the aggregation and movement of PC neurones in culture and they were blocked by the anti-LAPS18 antibody. Beads coupled with LAPS18 protein attached to PC neurones and the beads aggregated through PC cells but not by themselves, suggesting that LAPS18 may require a counterpart molecule for PC neurone aggregation. Conclusions: An increased expression and translocation of LAPS18 protein after paired conditioning may be needed for long-term memory formation and retention in the slug. Since genes homologous to LAPS18 genes in the land slug Limax are found from vertebrates including human, analysing the expression and function of LAPS18 may be important in understanding the molecular mechanism of memory formation and retention.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:51:07