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Titolo:
Unraveling peroxynitrite formation in biological systems
Autore:
Radi, R; Peluffo, G; Alvarez, MN; Naviliat, M; Cayota, A;
Indirizzi:
Univ Republ, Fac Med, Dept Bioquim, Montevideo 11800, Uruguay Univ RepublMontevideo Uruguay 11800 Bioquim, Montevideo 11800, Uruguay Univ Republ, Fac Med, Dept Reumatol, Montevideo, Uruguay Univ Republ Montevideo Uruguay Med, Dept Reumatol, Montevideo, Uruguay Univ Republ, Fac Med, Dept Med, Montevideo, Uruguay Univ Republ Montevideo Uruguay , Fac Med, Dept Med, Montevideo, Uruguay
Titolo Testata:
FREE RADICAL BIOLOGY AND MEDICINE
fascicolo: 5, volume: 30, anno: 2001,
pagine: 463 - 488
SICI:
0891-5849(20010301)30:5<463:UPFIBS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; PERFORMANCE LIQUID-CHROMATOGRAPHY; MANGANESE-SUPEROXIDE-DISMUTASE; FREE-RADICAL FORMATION; MASS-SPECTROMETRIC QUANTIFICATION; AMYOTROPHIC-LATERAL-SCLEROSIS; PROTEIN-BOUND 3-NITROTYROSINE; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; MITOCHONDRIAL ELECTRON-TRANSPORT; OXIDATIVE STRESS MEASUREMENTS;
Keywords:
nitric oxide; superoxide; peroxynitrite; hydroxyl radical; nitrogen dioxide; 3-nitrotyrosine; free radicals; detection; methods;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
200
Recensione:
Indirizzi per estratti:
Indirizzo: Radi, R Univ Republ, Fac Med, Dept Bioquim, Avda Gen Flores 2125, Montevideo 11800, Uruguay Univ Republ Avda Gen Flores 2125 Montevideo Uruguay 11800 Uruguay
Citazione:
R. Radi et al., "Unraveling peroxynitrite formation in biological systems", FREE RAD B, 30(5), 2001, pp. 463-488

Abstract

Peroxynitrite promotes oxidative damage and is implicated in the pathophysiology of various diseases that involve accelerated rates of nitric oxide and superoxide formation. The unambiguous detection of peroxynitrite in biological systems is, however, difficult due to the combination of a short biological half-life, limited diffusion, multiple target molecule reactions, and participation of alternative oxidation/nitration pathways. In this review, we provide the conceptual framework and a comprehensive analysis of the current experimental strategies that can serve to unequivocally define the existence and quantitation of peroxynitrite in biological systems of different levels of organization and complexity. (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 18:11:13