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Titolo:
Smoking, but not lipids, lipoprotein (a) and antibodies against oxidised LDL, is correlated to the expansion of abdominal aortic aneurysms
Autore:
Lindholt, JS; Heegaard, NHH; Vammen, S; Fasting, H; Henneberg, EW; Heickendorff, L;
Indirizzi:
Hosp Viborg, Dept Vasc Surg, Viborg, Denmark Hosp Viborg Viborg DenmarkHosp Viborg, Dept Vasc Surg, Viborg, Denmark Statens Serum Inst, Dept Autoimmunol, DK-2300 Copenhagen, Denmark Statens Serum Inst Copenhagen Denmark DK-2300 K-2300 Copenhagen, Denmark Univ Aarhus, Aarhus Kommune Hosp, Dept Clin Biochem, DK-8000 Aarhus C, Denmark Univ Aarhus Aarhus Denmark C ept Clin Biochem, DK-8000 Aarhus C, Denmark
Titolo Testata:
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
fascicolo: 1, volume: 21, anno: 2001,
pagine: 51 - 56
SICI:
1078-5884(200101)21:1<51:SBNLL(>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; BETA-ADRENERGIC-BLOCKADE; RISK-FACTORS; GROWTH-RATE; ATHEROSCLEROSIS; DISEASE; PROPRANOLOL; CHOLESTEROL; PROGRESSION; MASS;
Keywords:
smoking; lipids; oxidized low density lipoprotein; lipoprotein (a); abdominal aortic aneurysm; atherosclerosis; progression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Lindholt, JS Laerkevej 11, DK-8900 Randers, Denmark Laerkevej 11 RandersDenmark DK-8900 -8900 Randers, Denmark
Citazione:
J.S. Lindholt et al., "Smoking, but not lipids, lipoprotein (a) and antibodies against oxidised LDL, is correlated to the expansion of abdominal aortic aneurysms", EUR J VAS E, 21(1), 2001, pp. 51-56

Abstract

Objectives: to study the role of smoking, lipids, lipoprotein (a), and autoantibodies against oxidised low density lipoprotein (Ab-oxLDL) in the expansion of small abdominal aortic aneurysms (AAA). To study the role of Ab-oxLDL and lp(a) in the progression of lower limb atherosclerosis. Methods and Materials: one hundred and thirty-eight male patients with AAAwere interviewed, examined, and their serum lipids and S-Ab-oxLDL determined. Of these, 117 were followed annually with ultrasound and underwent control scans and blood pressure measurements for a mean of 2.5 (range 1-5) years. Results: initial AAA size, smoking and level of triglycerides were positively correlated to increased aneurysmal expansion, while beta-blocker medication was associated with decreased expansion. Besides initial AAA size, only smoking and persisting significance after adjustment of the other significant variables. Initial ankle brachial pressure index (ABI) and Lp(A) but not ab-oxLDL were significantly correlated to ABI change. Conclusion: smoking cessation may inhibit aneurysmal expansion. Lipids seem to play a minor role in the progression of AAA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:15:52