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Titolo:
Differences in (TC)-T-99m-HMPAO brain SPET perfusion imaging between Tourette's syndrome and chronic tic disorder in children
Autore:
Chiu, NT; Chang, YC; Leer, BF; Huang, CC; Wang, ST;
Indirizzi:
Natl Cheng Kung Univ, Coll Med, Dept Pediat, Tainan 704, Taiwan Natl ChengKung Univ Tainan Taiwan 704 , Dept Pediat, Tainan 704, Taiwan Natl Cheng Kung Univ, Coll Med, Dept Nucl Med, Tainan 704, Taiwan Natl Cheng Kung Univ Tainan Taiwan 704 Dept Nucl Med, Tainan 704, Taiwan Kaohsiung Chang Kang Childrens Hosp, Dept Pediat, Kaohsiung, Taiwan Kaohsiung Chang Kang Childrens Hosp Kaohsiung Taiwan Kaohsiung, Taiwan Natl Cheng Kung Univ, Coll Med, Dept Publ Hlth, Tainan 704, Taiwan Natl Cheng Kung Univ Tainan Taiwan 704 ept Publ Hlth, Tainan 704, Taiwan
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 2, volume: 28, anno: 2001,
pagine: 183 - 190
SICI:
0340-6997(200102)28:2<183:DI(BSP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; TC-99M HMPAO SPECT; TECHNETIUM-99M-HMPAO SPECT; FUNCTIONAL NEUROANATOMY; BASAL GANGLIA; FDG-PET; METABOLISM;
Keywords:
technetium-99m hexamethylpropylene amine; oxime; regional cerebral blood flow; brain single-photon emission tomography; Tourette's syndrome; chronic tic disorder;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Huang, CC Natl Cheng Kung Univ, Coll Med, Dept Pediat, 138 Sheng Li Rd, Tainan 704, Taiwan Natl Cheng Kung Univ 138 Sheng Li Rd Tainan Taiwan 704 , Taiwan
Citazione:
N.T. Chiu et al., "Differences in (TC)-T-99m-HMPAO brain SPET perfusion imaging between Tourette's syndrome and chronic tic disorder in children", EUR J NUCL, 28(2), 2001, pp. 183-190

Abstract

Early differential diagnosis between Tourette's syndrome and chronic tic disorder is difficult but important because both the outcome and the treatment of these two childhood-onset diseases are distinct. We assessed the sensitivity and specificity of brain single-photon emission tomography (SPET) perfusion imaging in distinguishing the two diseases, and characterized their different cerebral perfusion patterns. Twenty-seven children with Tourette's syndrome and 11 with chronic tic disorder (mean age 9.5 and 8.6 years, respectively) underwent brain SPET with technetium-99m hexamethylpropylene amine oxime (HMPAO). Visual interpretation and semiquantitative analysis ofSPET images were performed. On visual interpretation, 22 of 27 (82%) of the Tourette's syndrome group had lesions characterized by decreased perfusion. The left hemisphere was more frequently involved. None of the children with chronic tic disorder had a visible abnormality. Semi-quantitative analysis showed that, compared with children with chronic tic disorder, childrenwith Tourette's syndrome had significantly lower perfusion in the left lateral temporal area and asymmetric perfusion in the dorsolateral frontal, lateral and medial temporal areas, In conclusion, using the visual approach, brain SPET perfusion imaging is sensitive and specific in differentiating Tourette's syndrome and chronic tic disorder. The perfusion difference between the two groups, demonstrated by semi-quantitative analysis, may be related more to the co-morbidity in Tourette's syndrome than to ties per se.

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Documento generato il 22/09/20 alle ore 10:53:19