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Titolo:
Decreased frontal serotonin 5-HT2a receptor binding index in deliberate self-harm patients
Autore:
Audenaert, K; Van Laere, K; Dumont, F; Slegers, G; Mertens, J; van Heeringen, C; Dierckx, RA;
Indirizzi:
State Univ Ghent Hosp, Dept Psychiat & Med Psychol, Unit Suicide Res, B-9000 Ghent, Belgium State Univ Ghent Hosp Ghent Belgium B-9000 de Res, B-9000 Ghent, Belgium State Univ Ghent Hosp, Dept Nucl Med, B-9000 Ghent, Belgium State Univ Ghent Hosp Ghent Belgium B-9000 cl Med, B-9000 Ghent, Belgium State Univ Ghent, Dept Radiopharm, B-9000 Ghent, Belgium State Univ GhentGhent Belgium B-9000 Radiopharm, B-9000 Ghent, Belgium VUB Cyclotron, Brussels, Belgium VUB Cyclotron Brussels BelgiumVUB Cyclotron, Brussels, Belgium
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 2, volume: 28, anno: 2001,
pagine: 175 - 182
SICI:
0340-6997(200102)28:2<175:DFS5RB>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOTON EMISSION TOMOGRAPHY; SUICIDE VICTIMS; ANTIDEPRESSANT TREATMENT; DEPRESSIVE-ILLNESS; I-123 5-I-R91150; MAJOR DEPRESSION; BLOOD-PLATELETS; F-18 SETOPERONE; HUMAN-BRAIN; SITES;
Keywords:
deliberate self-harm; attempted suicide; serotonin; serotonin-2a receptor; single-photon emission tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Audenaert, K State Univ Ghent Hosp, Dept Psychiat & Med Psychol, Unit Suicide Res, 1K13,Pintelaan 185, B-9000 Ghent, Belgium State Univ Ghent Hosp 1K13,Pintelaan 185 Ghent Belgium B-9000
Citazione:
K. Audenaert et al., "Decreased frontal serotonin 5-HT2a receptor binding index in deliberate self-harm patients", EUR J NUCL, 28(2), 2001, pp. 175-182

Abstract

Studies of serotonin metabolites in body fluids in attempted suicide patients and of post-mortem brain tissue of suicide victims have demonstrated the involvement of the serotonergic neurotransmission system in the pathogenesis of suicidal behaviour. Recently developed neuroimaging techniques offerthe unique possibility of investigating in vivo the functional characteristics of this system. In this study the 5-HT2a receptor population of patients who had recently attempted suicide was studied by means of the highly specific radio-iodinated 5-MT2a receptor antagonist 4-amino-N-[1-[3-(4-fluorophenoxy) propyl] -4-methyl-4-piperidinyl] -5-iodo-2-methoxybenzamide or I-123-5-I-R91150. Nine patients who had recently (1-7 days) attempted suicide and 12 age-matched healthy controls received an intravenous injection of 185 MBq I-123-5-I-R91150 and were scanned with high-resolution brain single-photon emission tomography (SPET), Stereotactic realigned images were analysed semi-quantitatively using predefined volumes of interest. Serotonin binding capacity was expressed as the ratio of specific to non-specific activity. The cerebellum was used as a measure of non-specific activity. An age-dependent 5-HT2a binding index was found, in agreement with previous literature, Deliberate self-harm patients had a significantly reduced mean frontal binding index after correction for age (P=0.002) when compared with controls. The reduction was more pronounced among deliberate self-injury patients (DSI) (P<0.001) than among deliberate self-poisoning patients (DSP). Frontal binding index was significantly lower in DSI patients than in DSP suicideattempters (P<0.001). It is concluded that brain SPET of the 5-MT2a serotonin receptor system in attempted suicide patients who are free of drugs influencing the serotonergic system shows in vive evidence of a decreased frontal binding index of the 5-HT2a receptor, indicating a decrease in the number and/or in the binding affinity of 5-MT2a receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 06:25:52