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Titolo:
Total parenteral nutrition after surgery rapidly increases serum leptin levels
Autore:
Elimam, A; Tjader, I; Norgren, S; Wernerman, J; Essen, P; Ljungqvist, O; Marcus, C;
Indirizzi:
Huddinge Univ Hosp, Dept Paediat, Endocrine Res Unit, Karolinska Inst, S-14186 Huddinge, Sweden Huddinge Univ Hosp Huddinge Sweden S-14186 nst, S-14186 Huddinge, Sweden Huddinge Univ Hosp, Dept Anaesthesia & Intens Care, Karolinska Inst, S-14186 Huddinge, Sweden Huddinge Univ Hosp Huddinge Sweden S-14186 nst, S-14186 Huddinge, Sweden Huddinge Univ Hosp, Dept Surg, Karolinska Inst, S-14186 Huddinge, Sweden Huddinge Univ Hosp Huddinge Sweden S-14186 nst, S-14186 Huddinge, Sweden
Titolo Testata:
EUROPEAN JOURNAL OF ENDOCRINOLOGY
fascicolo: 2, volume: 144, anno: 2001,
pagine: 123 - 128
SICI:
0804-4643(200102)144:2<123:TPNASR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY-MASS INDEX; GROWTH-HORMONE TREATMENT; FREE-FATTY-ACIDS; PLASMA LEPTIN; OBESE GENE; ABDOMINALLY OBESE; 3T3-L1 ADIPOCYTES; DEFICIENT ADULTS; EARLY-ONSET; FOOD-INTAKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Marcus, C Huddinge Univ Hosp, Dept Paediat, Endocrine Res Unit, KarolinskaInst, B62, S-14186 Huddinge, Sweden Huddinge Univ Hosp B62 Huddinge Sweden S-14186 Huddinge, Sweden
Citazione:
A. Elimam et al., "Total parenteral nutrition after surgery rapidly increases serum leptin levels", EUR J ENDOC, 144(2), 2001, pp. 123-128

Abstract

Objective: In humans, leptin is regulated by long-term changes in energy intake. However, short-term regulation of serum leptin by nutrients has beendifficult to show. The aim of this study was to investigate whether short periods of fasting and stress sensitise the leptin response to nutrients. Subjects and experimental protocol: Fourteen patients of normal weight undergoing elective open cholecystectomy were randomised into two groups. One group received saline infusion during surgery and for 24 h postoperatively. The other group also received saline during the surgical procedure, but total parenteral nutrition (TPN) was started immediately after surgery, Bloodsamples were drawn before as well as 2, 4, 8, 16, and 24 h after the startof surgery to determine the serum levels of leptin and other hormones. Results: Postoperative TPN induced a significant rise in serum leptin within 6 h, reaching a more than fourfold increase within 14 h (P < 0.001). Serum glucose and insulin levels increased within 2 h. Growth hormone and IGF-1 serum levels also increased significantly in the group receiving TPN. Serum cortisol levels increased postoperatively in both groups, which may explain why no significant reduction in serum leptin was observed in the group receiving saline. Free tri-iodothyronine (T3) decreased in both groups, while catecholamines were similar in the groups. Conclusion: During fasting and surgical stress, nutrients rapidly increased the serum leptin levels in humans in a manner similar to that previously reported in rodents. This may be mediated by increases in serum glucose, insulin and cortisol.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:25:15