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Titolo:
Clinical implications of glucocorticoid metabolism by 11 beta-hydroxysteroid dehydrogenases in target tissues
Autore:
Quinkler, M; Oelkers, W; Diederich, S;
Indirizzi:
Free Univ Berlin, Klinikum Benjamin Franklin, Dept Endocrinol, D-12200 Berlin, Germany Free Univ Berlin Berlin Germany D-12200 ocrinol, D-12200 Berlin, Germany
Titolo Testata:
EUROPEAN JOURNAL OF ENDOCRINOLOGY
fascicolo: 2, volume: 144, anno: 2001,
pagine: 87 - 97
SICI:
0804-4643(200102)144:2<87:CIOGMB>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
APPARENT MINERALOCORTICOID EXCESS; CORTISONE REDUCTASE DEFICIENCY; CONGENITAL ADRENAL-HYPERPLASIA; PREGNANCY-INDUCED HYPERTENSION; HUMAN KIDNEY; GROWTH-HORMONE; BLOOD-PRESSURE; HUMAN PLACENTA; RAT-BRAIN; IMMUNOHISTOCHEMICAL LOCALIZATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
122
Recensione:
Indirizzi per estratti:
Indirizzo: Quinkler, M Free Univ Berlin, Klinikum Benjamin Franklin, Div Endocrinol, Hindenburgdamm 30, D-12200 Berlin, Germany Free Univ Berlin Hindenburgdamm 30 Berlin Germany D-12200 any
Citazione:
M. Quinkler et al., "Clinical implications of glucocorticoid metabolism by 11 beta-hydroxysteroid dehydrogenases in target tissues", EUR J ENDOC, 144(2), 2001, pp. 87-97

Abstract

11 beta -Hydroxysteroid dehydrogenases (11 beta -HSD) are microsomal enzymes that catalyze the conversion of active glucocorticoids (GC) to their inactive 11-dehydro products and vice versa. Two isoenzymes of 11 beta -HSD have been characterized and cloned in human tissues. The tissue-specific metabolism of GC by these enzymes is important for mineralocorticoid (MC) and GC receptor occupancy and seems to play a crucial role in the pathogenesis of diseases such as apparent MC excess syndrome, and may play roles in hypertension, obesity and impaired hepatic glucose homeostasis. This article reviews the literature and examines the role and importance of 11 beta -HSD inhumans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 00:24:08