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Titolo:
Changes in myosin heavy chain composition with heavy resistance training in 60-to 75-year-old men and women
Autore:
Sharman, MJ; Newton, RU; Triplett-McBride, T; McGuigan, MRM; McBride, JM; Hakkinen, A; Hakkinen, K; Kraemer, WJ;
Indirizzi:
Ball State Univ, Human Performance Lab, Muncie, IN 47306 USA Ball State Univ Muncie IN USA 47306 Performance Lab, Muncie, IN 47306 USA So Cross Univ, Sch Exercise Sci & Sport Management, Lismore, Australia So Cross Univ Lismore Australia & Sport Management, Lismore, Australia Cent Hosp, Dept Phys Med & Rehabil, Jyvaskyla, Finland Cent Hosp Jyvaskyla Finland Dept Phys Med & Rehabil, Jyvaskyla, Finland Univ Jyvaskyla, Neuromuscular Res Ctr, Jyvaskyla, Finland Univ Jyvaskyla Jyvaskyla Finland romuscular Res Ctr, Jyvaskyla, Finland Univ Jyvaskyla, Dept Biol Phys Act, Jyvaskyla, Finland Univ Jyvaskyla Jyvaskyla Finland Dept Biol Phys Act, Jyvaskyla, Finland Univ Wisconsin, Dept Exercise & Sport Sci, La Crosse, WI 54601 USA Univ Wisconsin La Crosse WI USA 54601 Sport Sci, La Crosse, WI 54601 USA
Titolo Testata:
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1-2, volume: 84, anno: 2001,
pagine: 127 - 132
SICI:
1439-6319(200101/02)84:1-2<127:CIMHCC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SKELETAL-MUSCLE; GENE-EXPRESSION; ELDERLY MEN; STRENGTH; FIBERS; COEXPRESSION; HYPERTROPHY; ADAPTATIONS; RESPONSES; ISOFORMS;
Keywords:
aging; myosin; SDS-PAGE; strength;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Newton, RU Ball State Univ, Human Performance Lab, Muncie, IN 47306 USA Ball State Univ Muncie IN USA 47306 Lab, Muncie, IN 47306 USA
Citazione:
M.J. Sharman et al., "Changes in myosin heavy chain composition with heavy resistance training in 60-to 75-year-old men and women", EUR J A PHY, 84(1-2), 2001, pp. 127-132

Abstract

The purpose of this investigation was to assess the myosin heavy chain (MHC) expression in the vastus lateralis muscle from elderly men and women, and to determine whether heavy resistance training influences its expression. Twenty healthy, mildly physically active subjects gave their informed consent to participate in the study. The experimental group consisted of seven men and seven women [mean (SD) age 65.5 (4.1) years] and the control group consisted of three men and three women [mean (SD) age 62.3 (3.6) years]. The 6-month resistance training program was divided into two phases with weeks 1-12 consisting of high-intensity resistance training, and weeks 13-24 involving power training. Muscle biopsy samples were taken from the vastus lateralis muscle at week 0 and week 24 using the needle biopsy technique. Themale and female experimental groups both exhibited a significant decrease (P less than or equal to 0.05) in the percentage of MHC IIb, while the experimental female group also demonstrated a significant increase (P less thanor equal to 0.05) in the expression of MHC IIa, after 24 weeks of heavy resistance training. There was no change in MHC expression within the controlgroup. The male [130.4 (25.3) kg vs 171.1 (30.5) kg] and female [58.2 (8.3) kg vs 77.9 (11.1) kg] experimental groups exhibited a significant increase (P less than or equal to 0.05) in the maximal strength values for the 1 repetition maximum (1RM) squat exercise. The control group showed no change in strength for the 1RM squat exercise for either the male [115.8 (35.10 kgvs 123.8 (47.2) kg] or female [57.5 (99.0) kg vs 58.3 (2.9) kg] groups. The results clearly show that elderly subjects undergoing heavy resistance training have the ability to produce a similar shift in the expression of MHCisoforms from MHC IIb to MHC IIa, as has been shown to occur in younger subjects. This highlights the plasticity of human skeletal muscle in responseto heavy resistance training, even at older ages.

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Documento generato il 02/07/20 alle ore 19:17:48