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Titolo:
Do we need another randomized controlled trial of folic acid alone?
Autore:
Turner, LA; Morrison, H; Prabhakaran, VM;
Indirizzi:
Hlth Canada, Bur Reprod & Child Hlth, Ottawa, ON K1A 0L2, Canada Hlth Canada Ottawa ON Canada K1A 0L2 ild Hlth, Ottawa, ON K1A 0L2, Canada Hlth Canada, Canc Bur, Ottawa, ON K1A 0L2, Canada Hlth Canada Ottawa ON Canada K1A 0L2 Canc Bur, Ottawa, ON K1A 0L2, Canada London Hlth Sci Ctr, Dept Biochem, London, ON, Canada London Hlth Sci CtrLondon ON Canada r, Dept Biochem, London, ON, Canada
Titolo Testata:
EPIDEMIOLOGY
fascicolo: 2, volume: 12, anno: 2001,
pagine: 262 - 265
SICI:
1044-3983(200103)12:2<262:DWNARC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURAL-TUBE DEFECTS; PERICONCEPTIONAL VITAMIN SUPPLEMENTATION; HEALTHY VOLUNTEERS; ZINC DEFICIENCY; DIETARY-FOLATE; PREVENTION; ABSORPTION; PREGNANCY; RISK; IRON;
Keywords:
neural tube defects; prevention and control; dietary supplements; folic acid; therapeutic use; congenital anomalies; diet;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Turner, LA Hlth Canada, Bur Reprod & Child Hlth, HPB Bldg 7,PL 0701D,Tunneys Pasture,Ottawa, ON K1A 0L2, Canada Hlth Canada HPB Bldg 7,PL 0701D,Tunneys Pasture Ottawa ON Canada K1A 0L2
Citazione:
L.A. Turner et al., "Do we need another randomized controlled trial of folic acid alone?", EPIDEMIOLOG, 12(2), 2001, pp. 262-265

Abstract

As a public health strategy to help prevent neural tube defect affected pregnancies, enriched flour and pasta in the United States and Canada are being fortified with folic acid, and women are being advised to take supplementary folic acid around the time of pregnancy to ensure an adequate intake, But in spice of the recently published results of a public health campaign in China, the burden of proof that folic acid alone is responsible for a decreased risk of these birth defects rests on the results of a randomized controlled trial conducted by the Medical Research Council of the United Kingdom. Supporting evidence comes primarily from studies that have shown a protective effect of multivitamins containing folic acid as one of many nutrients, Based on a striking and potentially hazardous type of non-compliance observed in an earlier study in which a participant took multiple vitamin doses simultaneously and a suggestion of similar incidents in the Medical Research Council study, we conclude that a further randomized controlled trialof the protective effect of folic acid alone may be necessary.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:17:38