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Titolo:
Delayed ovulation and pregnancy outcome: effect of environmental toxicantson the neuroendocrine control of the ovary
Autore:
Stoker, TE; Goldman, JM; Cooper, RL;
Indirizzi:
US EPA, Natl Hlth & Environm Effects Res Lab, Reprod Toxicol Div, Gamete &Early Embryo Biol Branch, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711 Branch, Res Triangle Pk, NC 27711 USA US EPA, Natl Hlth & Environm Effects Res Lab, Reprod Toxicol Div, Endocrinol Branch, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711 Branch, Res Triangle Pk, NC 27711 USA
Titolo Testata:
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
fascicolo: 3, volume: 9, anno: 2001,
pagine: 117 - 129
SICI:
1382-6689(200101)9:3<117:DOAPOE>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-RELEASING HORMONE; FOLLICLE-STIMULATING-HORMONE; D-ASPARTATE RECEPTORS; LUTEINIZING-HORMONE; FEMALE RAT; NEUROPEPTIDE-Y; GONADOTROPIN-SECRETION; ECTOPIC PREGNANCY; GROWTH-HORMONE; LH SURGE;
Keywords:
delayed ovulation; toxicants; neuroendocrine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
94
Recensione:
Indirizzi per estratti:
Indirizzo: Stoker, TE US EPA, Natl Hlth & Environm Effects Res Lab, Reprod Toxicol Div, Gamete &Early Embryo Biol Branch, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711 Triangle Pk, NC 27711 USA
Citazione:
T.E. Stoker et al., "Delayed ovulation and pregnancy outcome: effect of environmental toxicantson the neuroendocrine control of the ovary", ENV TOX PH, 9(3), 2001, pp. 117-129

Abstract

In the female rat, we have shown that a burst exposure to environmental toxicants known to alter noradrenergic function will block the ovulatory surge of LH when administered during a sensitive period on the day of vaginal proestrus. Such treatments will delay ovulation by 24 h and affect embryo survival. These results demonstrate clearly that brief, appropriately timed, toxicant exposure can initiate a cascade of changes that can alter reproductive outcome. However, we also found that continued exposure to the same compound is without an apparent influence on the reproductive capacity of thefemale, indicating that the female can become tolerant to such adverse reproductive effects. These observations raise a number of questions concerning the approaches currently used to examine potential reproductive toxicants. In this review, we describe the consequences of appropriately timed exposures to chlordimeform and dithiocarbamates on the timing of ovulation and subsequent alterations in pregnancy outcome. We also review the available literature on phenobarbital delays in ovulation and oocyte function in the rodent and the relevance to ovulatory delays in the human. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 04:03:44