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Titolo:
Neurotransmitter concentrations and binding at dopamine receptors in rats after maternal exposure to 3,4,3 ',4 '-tetrachlorobiphenyl: the role of reduced thyroid hormone concentrations
Autore:
Roth-Harer, A; Lilienthal, H; Bubser, M; Kronthaler, U; Mundy, WR; Ward, TR; Schmidt, W; Winterhoff, H; Winneke, G;
Indirizzi:
Med Inst Environm Hyg, Dept Biol Psychol, D-40225 Dusseldorf, Germany Med Inst Environm Hyg Dusseldorf Germany D-40225 225 Dusseldorf, Germany Univ Tubingen, Dept Neuropharmacol, D-72074 Tubingen, Germany Univ Tubingen Tubingen Germany D-72074 rmacol, D-72074 Tubingen, Germany US EPA, Div Neurotoxicol, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711 oxicol, Res Triangle Pk, NC 27711 USA Univ Munster, Inst Pharmacol & Toxicol, D-48149 Munster, Germany Univ Munster Munster Germany D-48149 & Toxicol, D-48149 Munster, Germany
Titolo Testata:
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
fascicolo: 3, volume: 9, anno: 2001,
pagine: 103 - 115
SICI:
1382-6689(200101)9:3<103:NCABAD>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
UDP-GLUCURONOSYLTRANSFERASE INDUCERS; POLYCHLORINATED-BIPHENYLS AROCLOR-1254; NEONATAL NEUROLOGICAL DEVELOPMENT; SUBSTITUTED PCB CONGENERS; TYROSINE-HYDROXYLASE; LACTATIONAL EXPOSURE; DEIODINASE ACTIVITY; PERINATAL EXPOSURE; PREPUBERTAL RATS; ADULT-RATS;
Keywords:
PCB; propylthiouracil; thyroid hormones; TSH; neurotransmitter; dopamine receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Lilienthal, H Med Inst Environm Hyg, Dept Biol Psychol, Aufm Hennekamp 50,D-40225 Dusseldorf, Germany Med Inst Environm Hyg Aufm Hennekamp 50 Dusseldorf Germany D-40225
Citazione:
A. Roth-Harer et al., "Neurotransmitter concentrations and binding at dopamine receptors in rats after maternal exposure to 3,4,3 ',4 '-tetrachlorobiphenyl: the role of reduced thyroid hormone concentrations", ENV TOX PH, 9(3), 2001, pp. 103-115

Abstract

Polychlorinated biphenyls (PCBs) are environmental contaminants, which accumulate in the food chain and are transferred to the offspring during prenatal development through the placenta and postnatally via breast milk. It isreported that PCBs exert effects on thyroid hormone levels and brain neurotransmitter levels. Both actions may alter neuronal development. The aim ofthe present study was to investigate, if PCB-induced effects on concentrations of catecholamines and serotonin can be attributed to PCB-induced reductions in thyroid hormone concentrations. In addition, binding to dopamine D-1 and D-2 receptors was examined. Time-mated Wistar rats were treated prenatally with 1 mg 3,4,3',4'-tetrachlorobiphenyl (PCB 77)/kg bodyweight or the vehicle. A third group serving as the positive control received perinatally 5 mg propylthiouracil (PTU)/l drinking water. There were no overt toxic signs in dams or offspring. Thyroid hormone measurements demonstrated effects in dams and offspring up to postnatal day 40. In particular, total T-4 in serum and in the thyroid were decreased in PCB- and PTU-treated dams and offspring. Only PTU exposed rats exhibited significantly increased concentrations of TSH in the serum and pituitary. Measurement of neurotransmitters revealed changes in the PCB-exposed offspring at PND 40, while PTU-treatment was without effect. Dopamine and DOPAC a ere increased in the medial prefrontal cortex. In adulthood, there were no PCB-related effects on thyroid hormones and neurotransmitters. Binding studies of dopamine D-1 and D-2 receptors demonstrated that PCB and PTU had no influence on receptor concentration and affinity. Comparison of PCB 77 exposed offspring to PTU exposed offspring demonstrated differential effects on TSH and neurotransmitter levels, the latter result indicating that not all PCB-induced effects on the nervous system can be ascribed to decreases in thyroid hormone concentrations. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:14:44