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Titolo:
Prenatal exposure to methylmercury changes dopamine-modulated motor activity during early ontogeny: age and gender-dependent effects
Autore:
Gimenez-Llort, L; Ahlbom, E; Dare, E; Vahter, M; Ogren, SO; Ceccatelli, S;
Indirizzi:
Karolinska Inst, Inst Environm Med, Div Toxicol & Neurotoxicol, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 icol, S-17177 Stockholm, Sweden Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden Karolinska InstStockholm Sweden S-17177 osci, S-17177 Stockholm, Sweden Karolinska Inst, Inst Environm Med, Div Met Toxicol, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 icol, S-17177 Stockholm, Sweden
Titolo Testata:
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
fascicolo: 3, volume: 9, anno: 2001,
pagine: 61 - 70
SICI:
1382-6689(200101)9:3<61:PETMCD>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEYCHELLES CHILD-DEVELOPMENT; METHYL MERCURY; NUCLEUS-ACCUMBENS; FETAL METHYLMERCURY; LOCOMOTOR-ACTIVITY; D-3 RECEPTOR; RAT STRIATUM; IN-UTERO; BRAIN; SEX;
Keywords:
methylmercury; motor activity; dopamine D-2 receptor; male and female rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Ceccatelli, S Karolinska Inst, Inst Environm Med, Div Toxicol & Neurotoxicol, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 Stockholm, Sweden
Citazione:
L. Gimenez-Llort et al., "Prenatal exposure to methylmercury changes dopamine-modulated motor activity during early ontogeny: age and gender-dependent effects", ENV TOX PH, 9(3), 2001, pp. 61-70

Abstract

We have shown previously that prenatal exposure of rats to 0.5 mg/kg/day of methylmercury (MeHg) produces gender-dependent changes in motor activity in adulthood. In the present study we have investigated whether changes in motor activity could also be found during early ontogeny of the offspring. Pregnant rats were treated with MeHg from day 7 of pregnancy to day 7 of lactation. The habituation to a novel environment (spontaneous activity) and the response to stimulation of the dopaminergic system were studied on postnatal day 14 and 21. Measures of spontaneous activity showed a slight increase in MeHg-prenatal exposed male and female rats at 14 days, but not at 21days. Following administration of U91356A, a selective dopamine D-2 receptor agonist, a significantly lower dopamine-mediated locomotor activity was observed in the 21 day old MeHg-treated males, but not in females. These results show that prenatal exposure to MeHg alters postjunctional dopaminergic activity during the period of maturation of the dopamine system in the brain. Moreover, the gender-dependent susceptibility previously found in adulthood is already evident at the prepubertal stage. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 04:02:16