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Titolo:
Potential for polysialylated form of neural cell adhesion molecule-mediated neuroplasticity within the gonadotropin-releasing hormone neurosecretory system of the ewe
Autore:
Viguie, C; Jansen, HT; Glass, JD; Watanabe, M; Billings, HJ; Coolen, L; Lehman, MN; Karsch, FJ;
Indirizzi:
Univ Michigan, Reprod Sci Program, Dept Physiol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ept Physiol, Ann Arbor, MI 48109 USA Univ Cincinnati, Coll Med, Dept Cell Biol Neurobiol & Anat, Cincinnati, OH45267 USA Univ Cincinnati Cincinnati OH USA 45267 l & Anat, Cincinnati, OH45267 USA Kent State Univ, Dept Sci Biol, Kent, OH 44240 USA Kent State Univ Kent OH USA 44240 Univ, Dept Sci Biol, Kent, OH 44240 USA Case Western Reserve Univ, Rainbow Babies & Childrens Hosp, Dept Pediat, Div Pediat Cardiol, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA
Titolo Testata:
ENDOCRINOLOGY
fascicolo: 3, volume: 142, anno: 2001,
pagine: 1317 - 1324
SICI:
0013-7227(200103)142:3<1317:PFPFON>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED SYNAPTIC PLASTICITY; NEGATIVE FEEDBACK ACTION; MONKEY MACACA-MULATTA; LUTEINIZING-HORMONE; RHESUS-MONKEY; ESTROUS-CYCLE; PHYSIOLOGICAL STIMULI; GLIAL PLASTICITY; ARCUATE NUCLEUS; MIGRATION ROUTE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Karsch, FJ Univ Michigan, Reprod Sci Program, Dept Physiol, 300 N Ingalls Bldg,Room 1101 SW, Ann Arbor, MI 48109 USA Univ Michigan 300 N Ingalls Bldg,Room 1101 SW Ann Arbor MI USA 48109
Citazione:
C. Viguie et al., "Potential for polysialylated form of neural cell adhesion molecule-mediated neuroplasticity within the gonadotropin-releasing hormone neurosecretory system of the ewe", ENDOCRINOL, 142(3), 2001, pp. 1317-1324

Abstract

The GnRH neurosecretory system undergoes marked structural and functional changes throughout life. The initial goal of this study was to examine the neuroanatomical relationship between GnRH neurons and a glycoprotein implicated in neuroplasticity, the polysialylated form of neural cell adhesion molecule (PSA-NCAM). Using dual label immunocytochemistry in conjunction withconfocal microscopy, we determined that fibers, terminals, and perikarya of GnRH neurons in adult ovariectomized ewes are intimately associated with PSA-NCAM. In the preoptic area, intense PSA-NCAM. immunoreactivity was evident around the periphery of GnRH cell bodies. The second goal of this studywas to determine whether PSA-NCAM expression associated with GnRH neurons varies in conjunction with seasonal changes in the activity of the GnRH neurosecretory system in ovariectomized ewes treated with constant release implants of estradiol. During the breeding season when reproductive neuroendocrine activity was enhanced, the expression of PSA-NCAM immunoreactivity associated with GnRH neurons was significantly greater than that during anestrus when GnRH secretion was reduced. This difference, which occurred despitean unchanging ovarian steroid milieu, was not observed in preoptic area structures devoid of GnRH immunoreactivity, suggesting that the seasonal change is at least partially specific to the GnRH system. The close associationbetween PSA-NCAM and GnRH neurons and the change in this relationship in conjunction with seasonal alterations in GnRH secretion provide anatomical evidence that this molecule may contribute to seasonal remodeling of the GnRH neurosecretory system of the adult.

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Documento generato il 02/12/20 alle ore 07:12:09